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Atf7 activating transcription factor 7 [ Mus musculus (house mouse) ]

Gene ID: 223922, updated on 16-Jun-2026
Official Symbol
Atf7provided by MGI
Official Full Name
activating transcription factor 7provided by MGI
Primary source
MGI:MGI:2443472
See related
Ensembl:ENSMUSG00000099083 AllianceGenome:MGI:2443472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110012F10Rik; 9430065F09Rik; C130020M04Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Involved in several processes, including hematopoietic progenitor cell differentiation; hepatocyte apoptotic process; and p38MAPK cascade. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human ATF7 (activating transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in mammary gland adult (RPKM 18.6), limb E14.5 (RPKM 18.1) and 28 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Atf7 in Genome Data Viewer
Location:
15 F3; 15 57.66 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102434381..102533899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102525946..102625464, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene STARR-seq mESC enhancer starr_39849 Neighboring gene uncharacterized LOC105246046 Neighboring gene STARR-seq mESC enhancer starr_39850 Neighboring gene predicted gene, 25141 Neighboring gene ribosomal protein L39, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m(5) C Methylation of Atf7 mRNA. Wang K, et al. Adv Sci (Weinh), 2023 Dec. PMID 37870216, Free PMC Article
  2. ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet. Yoshida K, et al. Mol Cell, 2020 May 7. PMID 32197065
  3. Stress-induced and ATF7-dependent epigenetic change influences cellular senescence. Maekawa T, et al. Genes Cells, 2019 Sep. PMID 31294895
  4. The Transcription Factor ATF7 Controls Adipocyte Differentiation and Thermogenic Gene Programming. Liu Y, et al. iScience, 2019 Mar 29. PMID 30826729, Free PMC Article
  5. ATF7 ablation prevents diet-induced obesity and insulin resistance. Liu Y, et al. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27498002

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m[5] C Methylation of Atf7 mRNA.
    Title: HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m(5) C Methylation of Atf7 mRNA.
  2. ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
    Title: ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
  3. ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
    Title: ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
  4. ATF7 is involved in regulating lifespan and stress-induced senescence via p16Ink4a gene transcription.
    Title: Stress-induced and ATF7-dependent epigenetic change influences cellular senescence.
  5. Here, we show that TNF-alpha, which is induced by various psychological stresses, induces the p38-dependent phosphorylation of ATF7, a stress-responsive chromatin regulator, in mouse testicular germ cells. This caused a release of ATF7 from the TERRA gene promoter in the subtelomeric region, which disrupted heterochromatin and induced TERRA.
    Title: Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7.
  6. A decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice.
    Title: ATF7 mediates TNF-α-induced telomere shortening.
  7. ATF7 ablation prevents diet-induced obesity and insulin resistance.
    Title: ATF7 ablation prevents diet-induced obesity and insulin resistance.
  8. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
    Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
  9. Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei.
    Title: Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: Npff

Homology

Clone Names

  • MGC31554

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in liver development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
cyclic AMP-dependent transcription factor ATF-7
Names
cAMP-dependent transcription factor ATF-7
transcription factor ATF-A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310066.1 → NP_001296995.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

    See identical proteins and their annotated locations for NP_001296995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC123870, AC137156, AK039648, AK164412
    Consensus CDS
    CCDS84198.1
    UniProtKB/Swiss-Prot
    Q8R0S1
    UniProtKB/TrEMBL
    Q3TZR9, Q3U2X8, V9GXT2
    Related
    ENSMUSP00000139308.2, ENSMUST00000184485.8
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001310067.1 → NP_001296996.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

    See identical proteins and their annotated locations for NP_001296996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC123870, AC137156, AK039648, AK164412
    Consensus CDS
    CCDS84198.1
    UniProtKB/Swiss-Prot
    Q8R0S1
    UniProtKB/TrEMBL
    Q3TZR9, Q3U2X8, V9GXT2
    Related
    ENSMUSP00000139181.2, ENSMUST00000184616.8
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001310070.1 → NP_001296999.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123870, AK047901, AK164412
    Consensus CDS
    CCDS84197.1
    UniProtKB/Swiss-Prot
    Q8R0S1
    UniProtKB/TrEMBL
    Q3U2X8, V9GXN6
    Related
    ENSMUSP00000139243.2, ENSMUST00000184906.8
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102434381..102533899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_146065.1: Suppressed sequence

    Description
    NM_146065.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0S1.1 GenPept UniProtKB/Swiss-Prot:Q8R0S1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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