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Atf7 activating transcription factor 7 [ Mus musculus (house mouse) ]

Gene ID: 223922, updated on 8-Dec-2022

Summary

Official Symbol
Atf7provided by MGI
Official Full Name
activating transcription factor 7provided by MGI
Primary source
MGI:MGI:2443472
See related
Ensembl:ENSMUSG00000099083 AllianceGenome:MGI:2443472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110012F10Rik; 9430065F09Rik; C130020M04Rik
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Involved in several processes, including animal organ development; hepatocyte apoptotic process; and p38MAPK cascade. Predicted to be located in nucleoplasm. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human ATF7 (activating transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 18.6), limb E14.5 (RPKM 18.1) and 28 other tissues See more
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Genomic context

See Atf7 in Genome Data Viewer
Location:
15; 15 F3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102434381..102533899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102525946..102625464, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene uncharacterized LOC105246046 Neighboring gene predicted gene, 25141 Neighboring gene ribosomal protein L39, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Npff

Homology

Clone Names

  • MGC31554

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-7
Names
cAMP-dependent transcription factor ATF-7
transcription factor ATF-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310066.1NP_001296995.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

    See identical proteins and their annotated locations for NP_001296995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC123870, AC137156, AK039648, AK164412
    Consensus CDS
    CCDS84198.1
    UniProtKB/TrEMBL
    A0A6P5R897, Q3TZR9
    Related
    ENSMUSP00000139308.2, ENSMUST00000184485.8
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001310067.1NP_001296996.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

    See identical proteins and their annotated locations for NP_001296996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC123870, AC137156, AK039648, AK164412
    Consensus CDS
    CCDS84198.1
    UniProtKB/TrEMBL
    A0A6P5R897, Q3TZR9
    Related
    ENSMUSP00000139181.2, ENSMUST00000184616.8
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001310070.1NP_001296999.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123870, AK047901, AK164412
    Consensus CDS
    CCDS84197.1
    UniProtKB/TrEMBL
    V9GXN6
    Related
    ENSMUSP00000139243.2, ENSMUST00000184906.8
    Conserved Domains (3) summary
    cd12192
    Location:4784
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:931
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102434381..102533899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_146065.1: Suppressed sequence

    Description
    NM_146065.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.