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Soat2 sterol O-acyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 223920, updated on 9-Mar-2023

Summary

Official Symbol
Soat2provided by MGI
Official Full Name
sterol O-acyltransferase 2provided by MGI
Primary source
MGI:MGI:1332226
See related
Ensembl:ENSMUSG00000023045 AllianceGenome:MGI:1332226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACAT2; D15Wsu97e
Summary
Enables sterol O-acyltransferase activity. Acts upstream of or within cholesterol metabolic process. Located in membrane. Human ortholog(s) of this gene implicated in coronary artery disease and hepatocellular carcinoma. Orthologous to human SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 116.4), small intestine adult (RPKM 111.2) and 6 other tissues See more
Orthologs
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Genomic context

See Soat2 in Genome Data Viewer
Location:
15 F2; 15 57.33 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102058853..102071871)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102150415..102163469)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SPRY domain containing 3 Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene integrin beta 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC36039

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables cholesterol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables sterol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sterol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol storage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sterol O-acyltransferase 2
Names
ACAT-2
acyl-CoA:cholesterol acyltransferase
acyl-coenzyme A:cholesterol acyltransferase 2
cholesterol acyltransferase 2
NP_666176.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146064.1NP_666176.1  sterol O-acyltransferase 2

    See identical proteins and their annotated locations for NP_666176.1

    Status: PROVISIONAL

    Source sequence(s)
    BC025931
    Consensus CDS
    CCDS27872.1
    UniProtKB/Swiss-Prot
    O88908, Q8R0Y9
    Related
    ENSMUSP00000023806.7, ENSMUST00000023806.14
    Conserved Domains (1) summary
    pfam03062
    Location:263497
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102058853..102071871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938833.1 RNA Sequence