Rnd1 Rho family GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnd1provided by MGI
Official Full Name: Rho family GTPase 1provided by MGI
Primary source: MGI:MGI:2444878
See related: Ensembl:ENSMUSG00000054855 AllianceGenome:MGI:2444878
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arhs; A830014L09Rik
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; neuron remodeling; and regulation of cell shape. Predicted to be located in actin cytoskeleton; adherens junction; and intracellular membrane-bounded organelle. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RND1 (Rho family GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 7.9), cerebellum adult (RPKM 7.7) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 F1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98567086..98575342, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98669205..98677461, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.
Title: Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

AI451046 (e-PCR)
- UniSTS:209142

Homology

Homologs of the Rnd1 gene: The Rnd1 gene is conserved in human, chimpanzee, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 300 organisms have orthologs with human gene Rnd1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho-related GTP-binding protein Rho6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172612.3 → NP_766200.1 rho-related GTP-binding protein Rho6

See identical proteins and their annotated locations for NP_766200.1

Status: PROVISIONAL

Source sequence(s)

AC156543

Consensus CDS

CCDS27801.1

UniProtKB/Swiss-Prot

Q8BLR7, Q8BYF2

UniProtKB/TrEMBL

A0A8C6G6I7

Related

ENSMUSP00000003451.5, ENSMUST00000003451.11

Conserved Domains (2) summary

smart00174
Location:16 → 190

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cl21455
Location:1 → 232

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases