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Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 [ Mus musculus (house mouse) ]

Gene ID: 223864, updated on 12-May-2024

Summary

Official Symbol
Rapgef3provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 3provided by MGI
Primary source
MGI:MGI:2441741
See related
Ensembl:ENSMUSG00000022469 AllianceGenome:MGI:2441741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epac; Epac1; 2310016P22Rik; 9330170P05Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in associative learning. Predicted to be located in several cellular components, including basolateral part of cell; brush border membrane; and distal axon. Predicted to colocalize with cortical actin cytoskeleton and plasma membrane. Is expressed in brain; heart; lung; and metanephros. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 30.5), thymus adult (RPKM 25.7) and 24 other tissues See more
Orthologs
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Genomic context

See Rapgef3 in Genome Data Viewer
Location:
15 F1; 15 53.74 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97637886..97666300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97744770..97768419, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene endonuclease, polyU-specific Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97580414-97580523 Neighboring gene predicted gene, 33531 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene histone deacetylase 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (14)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC19192

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of syncytium formation by plasma membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of syncytium formation by plasma membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor cell terminal bouton ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
located_in rod bipolar cell terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 3
Names
Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
cAMP-GEFI
cAMP-regulated guanine nucleotide exchange factor I
exchange protein directly activated by cAMP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177810.1NP_001171281.1  rap guanine nucleotide exchange factor 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC104225, AK034265, AK142594, CJ051320
    Consensus CDS
    CCDS49714.1
    UniProtKB/TrEMBL
    Q3UQC2
    Related
    ENSMUSP00000116426.3, ENSMUST00000126854.9
    Conserved Domains (4) summary
    smart00147
    Location:661926
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:387496
    RasGEF_N; RasGEF N-terminal motif
  2. NM_001177811.1NP_001171282.1  rap guanine nucleotide exchange factor 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC104225, AK034265, AK169430, CJ051320
    Consensus CDS
    CCDS49713.1
    UniProtKB/TrEMBL
    E9Q2E5, Q3TES7
    Related
    ENSMUSP00000120126.3, ENSMUST00000128775.9
    Conserved Domains (5) summary
    cd06224
    Location:392513
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:661909
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    COG0664
    Location:268346
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  3. NM_001357630.1NP_001344559.1  rap guanine nucleotide exchange factor 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4.
    Source sequence(s)
    AC104225
    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    cd06224
    Location:392513
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:661929
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  4. NM_144850.2NP_659099.2  rap guanine nucleotide exchange factor 3 isoform 2

    See identical proteins and their annotated locations for NP_659099.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC104225
    Consensus CDS
    CCDS37187.2
    UniProtKB/Swiss-Prot
    Q8BZK9, Q8R1R1, Q8VCC8
    UniProtKB/TrEMBL
    Q3UQC2
    Related
    ENSMUSP00000118148.3, ENSMUST00000129223.9
    Conserved Domains (5) summary
    cd06224
    Location:392513
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:661918
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    COG0664
    Location:268346
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97637886..97666300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248523.2XP_030104383.1  rap guanine nucleotide exchange factor 3 isoform X9

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:661926
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:387496
    RasGEF_N; RasGEF N-terminal motif
  2. XM_036159382.1XP_036015275.1  rap guanine nucleotide exchange factor 3 isoform X14

    UniProtKB/TrEMBL
    H3BK39
    Conserved Domains (4) summary
    smart00147
    Location:568833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:154263
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00618
    Location:294403
    RasGEF_N; RasGEF N-terminal motif
    cl02442
    Location:36130
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
  3. XM_036159375.1XP_036015268.1  rap guanine nucleotide exchange factor 3 isoform X2

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:695960
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:281390
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131257
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:421530
    RasGEF_N; RasGEF N-terminal motif
  4. XM_017316583.3XP_017172072.1  rap guanine nucleotide exchange factor 3 isoform X4

    UniProtKB/TrEMBL
    Q3UQC2
    Related
    ENSMUSP00000135238.2, ENSMUST00000177352.8
    Conserved Domains (4) summary
    smart00147
    Location:692957
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:278387
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131254
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:418527
    RasGEF_N; RasGEF N-terminal motif
  5. XM_017316585.2XP_017172074.1  rap guanine nucleotide exchange factor 3 isoform X17

    Conserved Domains (2) summary
    smart00147
    Location:233498
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl02520
    Location:185
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
  6. XM_030248524.1XP_030104384.1  rap guanine nucleotide exchange factor 3 isoform X10

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:661915
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:247356
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100223
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:387496
    RasGEF_N; RasGEF N-terminal motif
  7. XM_036159379.1XP_036015272.1  rap guanine nucleotide exchange factor 3 isoform X8

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:664932
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:250359
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100226
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:390499
    RasGEF_N; RasGEF N-terminal motif
  8. XM_036159378.1XP_036015271.1  rap guanine nucleotide exchange factor 3 isoform X8

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:664932
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:250359
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:100226
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:390499
    RasGEF_N; RasGEF N-terminal motif
  9. XM_036159381.1XP_036015274.1  rap guanine nucleotide exchange factor 3 isoform X13

    UniProtKB/TrEMBL
    H3BK39
    Conserved Domains (4) summary
    smart00147
    Location:571839
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:157266
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00618
    Location:297406
    RasGEF_N; RasGEF N-terminal motif
    cl02442
    Location:36133
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
  10. XM_011245602.4XP_011243904.1  rap guanine nucleotide exchange factor 3 isoform X12

    UniProtKB/TrEMBL
    H3BK39
    Conserved Domains (4) summary
    smart00147
    Location:619887
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:205314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:58181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:345454
    RasGEF_N; RasGEF N-terminal motif
  11. XM_036159380.1XP_036015273.1  rap guanine nucleotide exchange factor 3 isoform X11

    UniProtKB/TrEMBL
    H3BK39
    Conserved Domains (4) summary
    smart00147
    Location:622890
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:208317
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:58184
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:348457
    RasGEF_N; RasGEF N-terminal motif
  12. XM_036159377.1XP_036015270.1  rap guanine nucleotide exchange factor 3 isoform X7

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:695949
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:281390
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131257
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:421530
    RasGEF_N; RasGEF N-terminal motif
  13. XM_036159376.1XP_036015269.1  rap guanine nucleotide exchange factor 3 isoform X5

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:695952
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:281390
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131257
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:421530
    RasGEF_N; RasGEF N-terminal motif
  14. XM_036159374.1XP_036015267.1  rap guanine nucleotide exchange factor 3 isoform X1

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:695963
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:281390
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131257
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:421530
    RasGEF_N; RasGEF N-terminal motif
  15. XM_017316584.3XP_017172073.1  rap guanine nucleotide exchange factor 3 isoform X6

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:692949
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:278387
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131254
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:418527
    RasGEF_N; RasGEF N-terminal motif
  16. XM_017316582.3XP_017172071.1  rap guanine nucleotide exchange factor 3 isoform X3

    UniProtKB/TrEMBL
    Q3UQC2
    Conserved Domains (4) summary
    smart00147
    Location:692960
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:278387
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:131254
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:418527
    RasGEF_N; RasGEF N-terminal motif
  17. XM_011245603.1XP_011243905.1  rap guanine nucleotide exchange factor 3 isoform X16

    Conserved Domains (2) summary
    smart00147
    Location:233501
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl02520
    Location:185
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
  18. XM_036159383.1XP_036015276.1  rap guanine nucleotide exchange factor 3 isoform X15

    Conserved Domains (2) summary
    cd06224
    Location:4125
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:273541
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RNA

  1. XR_004938829.1 RNA Sequence

  2. XR_001781519.3 RNA Sequence

  3. XR_004938830.1 RNA Sequence

  4. XR_004938831.1 RNA Sequence

  5. XR_004938832.1 RNA Sequence