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Alg12 asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase) [ Mus musculus (house mouse) ]

Gene ID: 223774, updated on 10-Mar-2023

Summary

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Official Symbol
Alg12provided by MGI
Official Full Name
asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase)provided by MGI
Primary source
MGI:MGI:2385025
See related
Ensembl:ENSMUSG00000035845 AllianceGenome:MGI:2385025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ECM39
Summary
Predicted to enable alpha-1,6-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to act upstream of or within dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum lumen and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.5), testis adult (RPKM 11.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Alg12 in Genome Data Viewer
Location:
15; 15 E3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88689446..88703521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88805243..88819318, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene bromodomain containing 1 Neighboring gene zinc finger, BED type containing 4 Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene predicted gene, 23144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the 5'-flanking region of the mouse asparagine-linked glycosylation 12 homolog gene. Oh-Hashi K, et al. Cell Mol Biol Lett, 2013 Sep. PMID 23818223, Free PMC Article
  2. Role of an ER stress response element in regulating the bidirectional promoter of the mouse CRELD2 - ALG12 gene pair. Oh-Hashi K, et al. BMC Genomics, 2010 Nov 25. PMID 21106106, Free PMC Article
  3. Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. Chantret I, et al. J Biol Chem, 2002 Jul 12. PMID 11983712
  4. Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. Oriol R, et al. Mol Biol Evol, 2002 Sep. PMID 12200473
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC29374

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Names
asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase)
asparagine-linked glycosylation protein 12 homolog
dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase
mannosyltransferase ALG12 homolog
NP_001135829.1
NP_663452.1
XP_006520905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142357.2 → NP_001135829.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001135829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117700
    Consensus CDS
    CCDS49694.1
    UniProtKB/Swiss-Prot
    Q3UQK8, Q8VDB2
    Related
    ENSMUSP00000123935.2, ENSMUST00000162183.8
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. NM_001416017.1 → NP_001402946.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117700
    UniProtKB/Swiss-Prot
    Q3UQK8

  3. NM_001416018.1 → NP_001402947.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117700
    UniProtKB/Swiss-Prot
    Q3UQK8

  4. NM_001416019.1 → NP_001402948.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117700

  5. NM_145477.3 → NP_663452.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_663452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC117700
    Consensus CDS
    CCDS27732.1
    UniProtKB/Swiss-Prot
    Q8VDB2
    UniProtKB/TrEMBL
    Q8VCA2
    Related
    ENSMUSP00000043480.9, ENSMUST00000043087.15
    Conserved Domains (1) summary
    cl21590
    Location:17 → 232
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RNA

  1. NR_183241.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117700

  2. NR_183242.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117700

  3. NR_183243.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117700

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88689446..88703521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520842.2 → XP_006520905.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q8VDB2
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDB2.2 GenPept UniProtKB/Swiss-Prot:Q8VDB2

Gene LinkOut

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