U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wars1 tryptophanyl-tRNA synthetase1 [ Mus musculus (house mouse) ]

Gene ID: 22375, updated on 8-Jan-2023

Summary

Official Symbol
Wars1provided by MGI
Official Full Name
tryptophanyl-tRNA synthetase1provided by MGI
Primary source
MGI:MGI:104630
See related
Ensembl:ENSMUSG00000021266 AllianceGenome:MGI:104630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WRS; Wars; TrpRS
Summary
Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Wars1 in Genome Data Viewer
Location:
12; 12 F1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108825956..108860100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108860030..108894175, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene WD repeat domain 25 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tryptophan-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tryptophan-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tryptophan-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tryptophan--tRNA ligase, cytoplasmic
Names
tryptophanyl-tRNA synthetase, cytoplasmic
NP_001157786.1
NP_001157960.1
NP_035840.3
XP_006515882.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164314.2NP_001157786.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001157786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS49171.1
    UniProtKB/Swiss-Prot
    P32921
    UniProtKB/TrEMBL
    A0A8C6H6Q3, Q3U6U7
    Related
    ENSMUSP00000105474.4, ENSMUST00000109848.10
    Conserved Domains (3) summary
    PLN02486
    Location:89470
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:158467
    trpS; tryptophanyl-tRNA synthetase
    pfam00458
    Location:1668
    WHEP-TRS; WHEP-TRS domain
  2. NM_001164488.2NP_001157960.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001157960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS49171.1
    UniProtKB/Swiss-Prot
    P32921
    UniProtKB/TrEMBL
    A0A8C6H6Q3, Q3U6U7
    Related
    ENSMUSP00000125320.2, ENSMUST00000161410.8
    Conserved Domains (3) summary
    PLN02486
    Location:89470
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:158467
    trpS; tryptophanyl-tRNA synthetase
    pfam00458
    Location:1668
    WHEP-TRS; WHEP-TRS domain
  3. NM_001411907.1NP_001398836.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    Q9DC65
    UniProtKB/TrEMBL
    A0A8C6H4W0
  4. NM_001411908.1NP_001398837.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    Q9DC65
    UniProtKB/TrEMBL
    A0A8C6H4W0
  5. NM_001411909.1NP_001398838.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    Q9DC65
    UniProtKB/TrEMBL
    A0A8C6H4W0
  6. NM_001411910.1NP_001398839.1  tryptophan--tRNA ligase, cytoplasmic isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061
  7. NM_011710.4NP_035840.3  tryptophan--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_035840.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS26166.1
    UniProtKB/Swiss-Prot
    P32921, Q9DC65
    UniProtKB/TrEMBL
    A0A8C6H4W0
    Related
    ENSMUSP00000124625.2, ENSMUST00000161154.2
    Conserved Domains (2) summary
    PLN02486
    Location:89470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:1665
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

RNA

  1. NR_177976.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061
  2. NR_177977.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108825956..108860100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515819.3XP_006515882.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006515882.1

    UniProtKB/Swiss-Prot
    P32921, Q9DC65
    UniProtKB/TrEMBL
    A0A8C6H4W0
    Conserved Domains (2) summary
    PLN02486
    Location:89470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:1665
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...