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Ttll12 tubulin tyrosine ligase-like family, member 12 [ Mus musculus (house mouse) ]

Gene ID: 223723, updated on 12-May-2024

Summary

Official Symbol
Ttll12provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 12provided by MGI
Primary source
MGI:MGI:3039573
See related
Ensembl:ENSMUSG00000016757 AllianceGenome:MGI:3039573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D430005B17
Summary
Predicted to enable H4K20me3 modified histone binding activity and tubulin binding activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Predicted to act upstream of or within innate immune response. Predicted to be located in cytoplasm. Is expressed in liver; medulla oblongata basal plate mantle layer; metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 34.8), ovary adult (RPKM 22.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ttll12 in Genome Data Viewer
Location:
15 E1; 15 39.4 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83459295..83479358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83575094..83595157, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene translocator protein Neighboring gene STARR-positive B cell enhancer ABC_E8602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:83433173-83433433 Neighboring gene predicted gene, 52182 Neighboring gene signal peptide, CUB domain, EGF-like 1 Neighboring gene VISTA enhancer mm84 Neighboring gene Scube1 Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_39342 Neighboring gene predicted gene, 52183 Neighboring gene predicted gene, 33324

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables H4K20me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin--tyrosine ligase-like protein 12
Names
TTL domain protein
inactive tubulin--tyrosine ligase-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183017.2NP_898838.2  tubulin--tyrosine ligase-like protein 12

    See identical proteins and their annotated locations for NP_898838.2

    Status: VALIDATED

    Source sequence(s)
    AK084879, AK143496, AK150116
    Consensus CDS
    CCDS27706.1
    UniProtKB/Swiss-Prot
    Q3UDE2, Q7TPC3
    Related
    ENSMUSP00000016901.4, ENSMUST00000016901.5
    Conserved Domains (1) summary
    pfam03133
    Location:341630
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83459295..83479358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)