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Tomm22 translocase of outer mitochondrial membrane 22 [ Mus musculus (house mouse) ]

Gene ID: 223696, updated on 30-Apr-2024

Summary

Official Symbol
Tomm22provided by MGI
Official Full Name
translocase of outer mitochondrial membrane 22provided by MGI
Primary source
MGI:MGI:2450248
See related
Ensembl:ENSMUSG00000022427 AllianceGenome:MGI:2450248
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tom22; 2310047D01
Summary
Predicted to enable protein transmembrane transporter activity. Predicted to be involved in positive regulation of apoptotic process and protein insertion into mitochondrial outer membrane. Predicted to act upstream of or within protein transport. Located in mitochondrial inner membrane. Is expressed in genitourinary system. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 96.9), placenta adult (RPKM 50.2) and 28 other tissues See more
Orthologs
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Genomic context

See Tomm22 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79555069..79557063)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79670868..79672862)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member A Neighboring gene STARR-seq mESC enhancer starr_39191 Neighboring gene STARR-seq mESC enhancer starr_39193 Neighboring gene predicted gene, 30877 Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene Josephin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E389 Neighboring gene GTP binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein insertion into mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein insertion into mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM22 homolog
Names
translocase of outer membrane 22 kDa subunit homolog
translocase of outer mitochondrial membrane 22 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172609.3NP_766197.2  mitochondrial import receptor subunit TOM22 homolog

    See identical proteins and their annotated locations for NP_766197.2

    Status: PROVISIONAL

    Source sequence(s)
    AK009868
    Consensus CDS
    CCDS27646.1
    UniProtKB/Swiss-Prot
    Q543M4, Q9CPQ3, Q9D8D3
    UniProtKB/TrEMBL
    Q3UBW3
    Related
    ENSMUSP00000023062.4, ENSMUST00000023062.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79555069..79557063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)