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Ankrd54 ankyrin repeat domain 54 [ Mus musculus (house mouse) ]

Gene ID: 223690, updated on 26-Sep-2022

Summary

Official Symbol
Ankrd54provided by MGI
Official Full Name
ankyrin repeat domain 54provided by MGI
Primary source
MGI:MGI:2444209
See related
Ensembl:ENSMUSG00000033055 AllianceGenome:MGI:2444209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Liar; EST475269; EST1068184; C730048E16Rik
Summary
Enables protein kinase regulator activity. Acts upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of erythrocyte differentiation; and regulation of protein kinase activity. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including branchial arch; central nervous system; gut; immune system; and limb bud. Orthologous to human ANKRD54 (ankyrin repeat domain 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 104.4), duodenum adult (RPKM 40.9) and 26 other tissues See more
Orthologs
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Genomic context

See Ankrd54 in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78937294..78947129, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79053094..79062927, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) Neighboring gene galanin receptor 3 Neighboring gene predicted gene 3924 Neighboring gene eukaryotic translation initiation factor 3, subunit L Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 54
Names
lyn-interacting ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378988.1NP_001365917.1  ankyrin repeat domain-containing protein 54 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589670
    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117205
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001378989.1NP_001365918.1  ankyrin repeat domain-containing protein 54 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589670
    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117205
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001378990.1NP_001365919.1  ankyrin repeat domain-containing protein 54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL589670
    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117198
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_144849.1NP_659098.1  ankyrin repeat domain-containing protein 54 isoform 1

    See identical proteins and their annotated locations for NP_659098.1

    Status: VALIDATED

    Source sequence(s)
    BC014743
    Consensus CDS
    CCDS37139.1
    UniProtKB/Swiss-Prot
    Q3UZL7, Q91WK7
    UniProtKB/TrEMBL
    A7YB12
    Related
    ENSMUSP00000047042.5, ENSMUST00000040676.11
    Conserved Domains (3) summary
    cd00204
    Location:117231
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:117205
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78937294..78947129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245584.4XP_011243886.1  ankyrin repeat domain-containing protein 54 isoform X2

    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117198
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_036159352.1XP_036015245.1  ankyrin repeat domain-containing protein 54 isoform X3

    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117198
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_030248498.2XP_030104358.1  ankyrin repeat domain-containing protein 54 isoform X1

    Conserved Domains (2) summary
    sd00045
    Location:141172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:117205
    Ank_2; Ankyrin repeats (3 copies)