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Kcnk9 potassium channel, subfamily K, member 9 [ Mus musculus (house mouse) ]

Gene ID: 223604, updated on 18-Sep-2024

Summary

Official Symbol
Kcnk9provided by MGI
Official Full Name
potassium channel, subfamily K, member 9provided by MGI
Primary source
MGI:MGI:3521816
See related
Ensembl:ENSMUSG00000036760 AllianceGenome:MGI:3521816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Task3; A930009L07Rik
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 23.2), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnk9 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72373722..72422415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (72501873..72548614, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52221 Neighboring gene predicted gene, 24390 Neighboring gene STARR-positive B cell enhancer ABC_E8594 Neighboring gene STARR-seq mESC enhancer starr_38933 Neighboring gene STARR-seq mESC enhancer starr_38934 Neighboring gene trafficking protein particle complex 9 Neighboring gene predicted gene, 28020 Neighboring gene predicted gene, 53896 Neighboring gene paternally expressed 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 9
Names
TWIK-related acid-sensitive K(+) channel 3
acid-sensitive potassium channel protein TASK-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033876.2NP_001029048.1  potassium channel subfamily K member 9 precursor

    See identical proteins and their annotated locations for NP_001029048.1

    Status: VALIDATED

    Source sequence(s)
    AC118008, AC161195
    Consensus CDS
    CCDS27515.1
    UniProtKB/Swiss-Prot
    B2RT82, Q3LS21
    Related
    ENSMUSP00000038729.7, ENSMUST00000044624.8
    Conserved Domains (1) summary
    pfam07885
    Location:77132
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    72373722..72422415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520768.5XP_006520831.1  potassium channel subfamily K member 9 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:279334
    Ion_trans_2; Ion channel
  2. XM_036159328.1XP_036015221.1  potassium channel subfamily K member 9 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:279334
    Ion_trans_2; Ion channel