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Vip vasoactive intestinal polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22353, updated on 17-Jul-2024

Summary

Official Symbol
Vipprovided by MGI
Official Full Name
vasoactive intestinal polypeptideprovided by MGI
Primary source
MGI:MGI:98933
See related
Ensembl:ENSMUSG00000019772 AllianceGenome:MGI:98933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Biased expression in cortex adult (RPKM 14.9), large intestine adult (RPKM 14.5) and 5 other tissues See more
Orthologs
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Genomic context

See Vip in Genome Data Viewer
Location:
10 A1; 10 1.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5589131..5597617)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5639193..5647617)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene STARR-seq mESC enhancer starr_25602 Neighboring gene predicted gene, 51758 Neighboring gene STARR-seq mESC enhancer starr_25600 Neighboring gene STARR-positive B cell enhancer mm9_chr10:4746082-4746383 Neighboring gene myc target 1 Neighboring gene STARR-seq mESC enhancer starr_25599 Neighboring gene predicted gene, 40595 Neighboring gene predicted gene, 47679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107202

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to yeast ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
VIP peptides
Names
PHI, peptide histidine isoleucine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313969.1NP_001300898.1  VIP peptides isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK018599, BE990430
    UniProtKB/Swiss-Prot
    P32648
    Conserved Domains (1) summary
    pfam00123
    Location:82108
    Hormone_2; Peptide hormone
  2. NM_001407530.1NP_001394459.1  VIP peptides isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC157020, AC162387
    UniProtKB/Swiss-Prot
    P32648, Q9D2Z7, Q9QUN1
  3. NM_001407531.1NP_001394460.1  VIP peptides isoform 4 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC157020, AC162387
  4. NM_001407532.1NP_001394461.1  VIP peptides isoform 5 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC157020, AC162387
  5. NM_001407533.1NP_001394462.1  VIP peptides isoform 6 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC157020, AC162387
  6. NM_001407534.1NP_001394463.1  VIP peptides isoform 7 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC157020, AC162387
  7. NM_011702.3NP_035832.1  VIP peptides isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_035832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK018599, BE990430
    Consensus CDS
    CCDS56682.1
    UniProtKB/TrEMBL
    A0A0R4J003
    Related
    ENSMUSP00000019906.5, ENSMUST00000019906.6
    Conserved Domains (1) summary
    pfam00123
    Location:82108
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    5589131..5597617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512446.2XP_006512509.1  VIP peptides isoform X1

    Conserved Domains (1) summary
    pfam00123
    Location:82109
    Hormone_2; Peptide hormone