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Abra actin-binding Rho activating protein [ Mus musculus (house mouse) ]

Gene ID: 223513, updated on 12-May-2024

Summary

Official Symbol
Abraprovided by MGI
Official Full Name
actin-binding Rho activating proteinprovided by MGI
Primary source
MGI:MGI:2444891
See related
Ensembl:ENSMUSG00000042895 AllianceGenome:MGI:2444891
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STARS; C130068O12Rik
Summary
Enables actin binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of Rho protein signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein import into nucleus. Located in actin cytoskeleton and myofibril. Is expressed in embryo; heart; hindlimb muscle; and skeletal muscle. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 5.2), mammary gland adult (RPKM 1.9) and 3 other tissues See more
Orthologs
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Genomic context

See Abra in Genome Data Viewer
Location:
15 B3.1; 15 16.42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (41728689..41733116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (41865293..41869720, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38520 Neighboring gene predicted gene, 41312 Neighboring gene STARR-seq mESC enhancer starr_38522 Neighboring gene STARR-seq mESC enhancer starr_38523 Neighboring gene STARR-seq mESC enhancer starr_38524 Neighboring gene STARR-seq mESC enhancer starr_38525 Neighboring gene oxidation resistance 1 Neighboring gene STARR-seq mESC enhancer starr_38527 Neighboring gene STARR-seq mESC enhancer starr_38528 Neighboring gene STARR-positive B cell enhancer ABC_E10851 Neighboring gene STARR-seq mESC enhancer starr_38530 Neighboring gene STARR-seq mESC enhancer starr_38531 Neighboring gene STARR-seq mESC enhancer starr_38533 Neighboring gene predicted gene, 26854 Neighboring gene STARR-positive B cell enhancer mm9_chr15:41650297-41650598 Neighboring gene STARR-positive B cell enhancer ABC_E7365 Neighboring gene STARR-seq mESC enhancer starr_38536 Neighboring gene STARR-seq mESC enhancer starr_38537 Neighboring gene STARR-seq mESC enhancer starr_38538 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 24751

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin-binding Rho-activating protein
Names
striated muscle activator of Rho-dependent signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175456.4NP_780665.1  actin-binding Rho-activating protein

    See identical proteins and their annotated locations for NP_780665.1

    Status: PROVISIONAL

    Source sequence(s)
    AC129212
    Consensus CDS
    CCDS27449.1
    UniProtKB/Swiss-Prot
    Q0VB05, Q3UU01, Q8BLH3, Q8BUZ1, Q8K431
    Related
    ENSMUSP00000051973.6, ENSMUST00000054742.7
    Conserved Domains (1) summary
    pfam14705
    Location:299373
    Costars; Costars

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    41728689..41733116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)