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Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor [ Mus musculus (house mouse) ]

Gene ID: 22337, updated on 12-Jun-2018
Official Symbol
Vdrprovided by MGI
Official Full Name
vitamin D (1,25-dihydroxyvitamin D3) receptorprovided by MGI
Primary source
MGI:MGI:103076
See related
Ensembl:ENSMUSG00000022479 Vega:OTTMUSG00000026431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr1i1
Expression
Biased expression in duodenum adult (RPKM 78.3), colon adult (RPKM 58.5) and 3 other tissues See more
Orthologs
See Vdr in Genome Data Viewer
Location:
15; 15 F1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (97854427..97908296, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97684858..97738727, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene histone deacetylase 7 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene transmembrane protein 106C Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
CONTRIBUTES_TO DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitriol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitriol binding ISO
Inferred from Sequence Orthology
more info
 
calcitriol receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcitriol receptor activity ISO
Inferred from Sequence Orthology
more info
 
lithocholic acid binding ISO
Inferred from Sequence Orthology
more info
 
lithocholic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor activity, direct ligand regulated sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO vitamin D response element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to vitamin D response element binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
bile acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelium development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intestinal absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland branching involved in pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of apoptotic process involved in mammary gland involution IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of calcidiol 1-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dense fibrillar component ISO
Inferred from Sequence Orthology
more info
 
euchromatin ISO
Inferred from Sequence Orthology
more info
 
heterochromatin ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nuclear heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
vitamin D3 receptor
Names
1,25-dihydroxyvitamin D3 receptor
nuclear receptor subfamily 1 group I member 1
vitamin D receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009504.4NP_033530.2  vitamin D3 receptor

    See identical proteins and their annotated locations for NP_033530.2

    Status: VALIDATED

    Source sequence(s)
    AC158787, AK030339
    Consensus CDS
    CCDS27784.1
    UniProtKB/Swiss-Prot
    P48281
    Related
    ENSMUSP00000023119.8, OTTMUSP00000032572, ENSMUST00000023119.14, OTTMUST00000065367
    Conserved Domains (2) summary
    cd06933
    Location:124421
    NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
    cd06955
    Location:16122
    NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    97854427..97908296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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