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Vbp1 von Hippel-Lindau binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22327, updated on 1-Mar-2024

Summary

Official Symbol
Vbp1provided by MGI
Official Full Name
von Hippel-Lindau binding protein 1provided by MGI
Primary source
MGI:MGI:1333804
See related
Ensembl:ENSMUSG00000031197 AllianceGenome:MGI:1333804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VBP-1
Summary
Predicted to enable amyloid-beta binding activity; tubulin binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of amyloid fibril formation; protein folding; and tubulin complex assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of polysome and prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 30.1), CNS E14 (RPKM 25.7) and 15 other tissues See more
Orthologs
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Genomic context

See Vbp1 in Genome Data Viewer
Location:
X A7.3; X 38.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (74557903..74578552)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (75514297..75534946)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene predicted gene, 57668 Neighboring gene predicted gene 15384 Neighboring gene RAB39B, member RAS oncogene family Neighboring gene predicted gene 15063

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of prefoldin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prefoldin subunit 3
Names
VHL-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011692.2NP_035822.2  prefoldin subunit 3

    See identical proteins and their annotated locations for NP_035822.2

    Status: VALIDATED

    Source sequence(s)
    AK077923, BY134471, BY476349, DV066998
    Consensus CDS
    CCDS41032.1
    UniProtKB/Swiss-Prot
    P61759, Q3U6M9, Q9CPZ0
    UniProtKB/TrEMBL
    A3KMJ8
    Related
    ENSMUSP00000033540.6, ENSMUST00000033540.6
    Conserved Domains (1) summary
    cd00584
    Location:49180
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    74557903..74578552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)