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Vamp8 vesicle-associated membrane protein 8 [ Mus musculus (house mouse) ]

Gene ID: 22320, updated on 8-Dec-2022

Summary

Official Symbol
Vamp8provided by MGI
Official Full Name
vesicle-associated membrane protein 8provided by MGI
Primary source
MGI:MGI:1336882
See related
Ensembl:ENSMUSG00000050732 AllianceGenome:MGI:1336882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edb; endobrevin
Summary
Predicted to enable SNAP receptor activity; chloride channel inhibitor activity; and syntaxin binding activity. Involved in SNARE complex assembly and mucus secretion. Acts upstream of or within several processes, including cellular response to interferon-gamma; positive regulation of pancreatic amylase secretion; and zymogen granule exocytosis. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lysosome. Part of SNARE complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 138.4), lung adult (RPKM 135.0) and 24 other tissues See more
Orthologs
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Genomic context

See Vamp8 in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72362204..72367650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72385221..72390667, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 150A Neighboring gene ring finger protein 181 Neighboring gene vesicle-associated membrane protein 5 Neighboring gene predicted gene, 52494 Neighboring gene gamma-glutamyl carboxylase Neighboring gene methionine adenosyltransferase II, alpha Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome membrane docking ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucus secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of secretion by cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of pancreatic amylase secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within viral entry into host cell ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within zymogen granule exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in azurophil granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mucin granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mucin granule ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicle-associated membrane protein 8
Names
VAMP-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016794.3NP_058074.2  vesicle-associated membrane protein 8

    See identical proteins and their annotated locations for NP_058074.2

    Status: VALIDATED

    Source sequence(s)
    AC116115, AK013279
    Consensus CDS
    CCDS39514.1
    UniProtKB/Swiss-Prot
    O70404
    UniProtKB/TrEMBL
    A0A0R4J0R1, A0A6P5PVQ4, A0A8C6MS94
    Related
    ENSMUSP00000059501.10, ENSMUST00000059983.10
    Conserved Domains (1) summary
    cd15868
    Location:1076
    R-SNARE_VAMP8; SNARE motif of VAMP8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72362204..72367650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)