Vamp3 vesicle-associated membrane protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vamp3provided by MGI
Official Full Name: vesicle-associated membrane protein 3provided by MGI
Primary source: MGI:MGI:1321389
See related: Ensembl:ENSMUSG00000028955 AllianceGenome:MGI:1321389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ceb; VAMP-3; D130027G05Rik
Summary: Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Involved in SNARE complex assembly; positive regulation of receptor recycling; and substrate adhesion-dependent cell spreading. Acts upstream of or within Golgi to plasma membrane protein transport; calcium-ion regulated exocytosis; and cellular response to interferon-gamma. Located in several cellular components, including cell surface; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including adrenal gland; brain; and gonad. Orthologous to human VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 36.6), limb E14.5 (RPKM 28.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 E2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (151131762..151142410, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (151047305..151057953, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endocytic BDNF secretion regulated by Vamp3 in astrocytes.
Title: Endocytic BDNF secretion regulated by Vamp3 in astrocytes.
platelets are capable of a range of endocytosis steps, with VAMP-3 being pivotal in these processes.
Title: Cellubrevin/vesicle-associated membrane protein-3-mediated endocytosis and trafficking regulate platelet functions.
VAMP3 is required for normal NKCC2 expression, renal function, and blood pressure.
Title: Vesicle-associated Membrane Protein 3 (VAMP3) Mediates Constitutive Trafficking of the Renal Co-transporter NKCC2 in Thick Ascending Limbs: ROLE IN RENAL FUNCTION AND BLOOD PRESSURE.
The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
Title: The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
Although a slight decrease in the rate of recovery of surviving bacteria was observed between 12 h and 36 h post-infection with Brucella melitensis, this was not significant indicating that VAMP3 is not involved in Brucella survival.
Title: Silencing of VAMP3 expression does not affect Brucella melitensis infection in mouse macrophages.
Protein kinase D activates GLUT4 translocation via a VAMP3-dependent trafficking step.
Title: Overexpression of vesicle-associated membrane protein (VAMP) 3, but not VAMP2, protects glucose transporter (GLUT) 4 protein translocation in an in vitro model of cardiac insulin resistance.
This important SNARE complex facilitates macrophage adhesion, spreading, and persistent macrophage migration on fibronectin through the delivery of VAMP3-positive membrane with its cargo to expand the plasma membrane.
Title: VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration.
VAMP3 mediates fusion of recycling endosome-derived vesicles with the oligodendroglial plasma membrane in the course of the secretory pathway
Title: Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
Data show that in VAMP-8-deficient cells constitutive vesicular trafficking mechanisms are perturbed as indicated by increased SNARE complex formation between VAMP-3 and SNAP-23.
Title: Increased formation of VAMP-3-containing SNARE complexes in mast cells from VAMP-8 deficient cells. appetite.
Simultaneous disruption of VAMPs 2, 3 and 8 completely inhibited insulin-stimulated GLUT4 insertion into the plasma membrane.
Title: Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC86703P1 (e-PCR)
- UniSTS:273548

G06229 (e-PCR)
- UniSTS:26004

Homology

Homologs of the Vamp3 gene: The Vamp3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 470 organisms have orthologs with human gene Vamp3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SNARE complex assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium-ion regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicle-associated membrane protein 3

Names: cellubrevin; synaptobrevin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.