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Vamp3 vesicle-associated membrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 22319, updated on 12-May-2024

Summary

Official Symbol
Vamp3provided by MGI
Official Full Name
vesicle-associated membrane protein 3provided by MGI
Primary source
MGI:MGI:1321389
See related
Ensembl:ENSMUSG00000028955 AllianceGenome:MGI:1321389
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ceb; VAMP-3; D130027G05Rik
Summary
Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Involved in SNARE complex assembly; positive regulation of receptor recycling; and substrate adhesion-dependent cell spreading. Acts upstream of or within Golgi to plasma membrane protein transport; calcium-ion regulated exocytosis; and cellular response to interferon-gamma. Located in several cellular components, including cell surface; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including adrenal gland; brain; and gonad. Orthologous to human VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 36.6), limb E14.5 (RPKM 28.5) and 28 other tissues See more
Orthologs
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Genomic context

See Vamp3 in Genome Data Viewer
Location:
4 E2; 4 81.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (151131762..151142410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (151047305..151057953, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30120 Neighboring gene STARR-positive B cell enhancer ABC_E1294 Neighboring gene period circadian clock 3 Neighboring gene urotensin 2 Neighboring gene predicted gene, 38529 Neighboring gene calmodulin binding transcription activator 1 Neighboring gene predicted gene 13090 Neighboring gene predicted gene, 46899

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein 3
Names
cellubrevin
synaptobrevin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009498.4NP_033524.1  vesicle-associated membrane protein 3

    See identical proteins and their annotated locations for NP_033524.1

    Status: PROVISIONAL

    Source sequence(s)
    AK051272
    Consensus CDS
    CCDS18979.1
    UniProtKB/Swiss-Prot
    P63024, Q3TH70, Q64271
    Related
    ENSMUSP00000030797.4, ENSMUST00000030797.4
    Conserved Domains (1) summary
    cd15870
    Location:1779
    R-SNARE_VAMP2; SNARE motif of VAMP2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    151131762..151142410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)