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ZNRF2 zinc and ring finger 2 [ Homo sapiens (human) ]

Gene ID: 223082, updated on 17-Jun-2019

Summary

Official Symbol
ZNRF2provided by HGNC
Official Full Name
zinc and ring finger 2provided by HGNC
Primary source
HGNC:HGNC:22316
See related
Ensembl:ENSG00000180233 MIM:612061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF202
Expression
Ubiquitous expression in testis (RPKM 15.0), colon (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNRF2 in Genome Data Viewer
Location:
7p14.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (30284597..30367689)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30323923..30407308)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375217 Neighboring gene uncharacterized LOC105375218 Neighboring gene HNF1 motif-containing MPRA enhancer 259 Neighboring gene microRNA 550a-1 Neighboring gene microRNA 550b-1 Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene long intergenic non-protein coding RNA 1176

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZNRF2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein polyubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF2
Names
RING finger protein 202
RING-type E3 ubiquitin transferase ZNRF2
protein Ells2
zinc and ring finger 2, E3 ubiquitin protein ligase
zinc finger/RING finger 2
zinc/RING finger protein 2
NP_667339.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147128.4NP_667339.1  E3 ubiquitin-protein ligase ZNRF2

    See identical proteins and their annotated locations for NP_667339.1

    Status: VALIDATED

    Source sequence(s)
    AF513707, AF527533, AK025240
    Consensus CDS
    CCDS5426.1
    UniProtKB/Swiss-Prot
    Q8NHG8
    UniProtKB/TrEMBL
    A0A090N8Y8
    Related
    ENSP00000323879.4, ENST00000323037.5
    Conserved Domains (1) summary
    pfam13639
    Location:197237
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    30284597..30367689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_926925.2 RNA Sequence

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