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ZNRF2 zinc and ring finger 2 [ Homo sapiens (human) ]

Gene ID: 223082, updated on 22-Sep-2022

Summary

Official Symbol
ZNRF2provided by HGNC
Official Full Name
zinc and ring finger 2provided by HGNC
Primary source
HGNC:HGNC:22316
See related
Ensembl:ENSG00000180233 MIM:612061; AllianceGenome:HGNC:22316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF202
Summary
Enables ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 15.0), colon (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNRF2 in Genome Data Viewer
Location:
7p14.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30284597..30367689)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30422290..30505386)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30324213..30407305)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375217 Neighboring gene uncharacterized LOC124901607 Neighboring gene uncharacterized LOC105375218 Neighboring gene HNF1 motif-containing MPRA enhancer 259 Neighboring gene microRNA 550a-1 Neighboring gene microRNA 550b-1 Neighboring gene Sharpr-MPRA regulatory region 6335 Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene long intergenic non-protein coding RNA 1176

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZNRF2 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF2
Names
RING finger protein 202
RING-type E3 ubiquitin transferase ZNRF2
protein Ells2
zinc and ring finger 2, E3 ubiquitin protein ligase
zinc finger/RING finger 2
zinc/RING finger protein 2
NP_667339.1
XP_047276004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147128.4NP_667339.1  E3 ubiquitin-protein ligase ZNRF2

    See identical proteins and their annotated locations for NP_667339.1

    Status: VALIDATED

    Source sequence(s)
    AF513707, AF527533, AK025240
    Consensus CDS
    CCDS5426.1
    UniProtKB/Swiss-Prot
    Q8NHG8
    UniProtKB/TrEMBL
    A0A090N8Y8
    Related
    ENSP00000323879.4, ENST00000323037.5
    Conserved Domains (1) summary
    pfam13639
    Location:197237
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    30284597..30367689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420048.1XP_047276004.1  E3 ubiquitin-protein ligase ZNRF2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHG8
    UniProtKB/TrEMBL
    A0A090N8Y8

RNA

  1. XR_007059991.1 RNA Sequence

  2. XR_926925.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    30422290..30505386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)