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Uxt ubiquitously expressed prefoldin like chaperone [ Mus musculus (house mouse) ]

Gene ID: 22294, updated on 19-Mar-2023

Summary

Official Symbol
Uxtprovided by MGI
Official Full Name
ubiquitously expressed prefoldin like chaperoneprovided by MGI
Primary source
MGI:MGI:1277988
See related
Ensembl:ENSMUSG00000001134 AllianceGenome:MGI:1277988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0910002B17Rik
Summary
Predicted to enable beta-tubulin binding activity; chromatin binding activity; and transcription corepressor activity. Predicted to be involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within apoptotic process. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be active in chromatin. Is expressed in several structures, including cerebellum; neural retina; and telencephalon. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 6.6), kidney adult (RPKM 6.5) and 28 other tissues See more
Orthologs
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Genomic context

See Uxt in Genome Data Viewer
Location:
X; X A1.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20817904..20828256, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20951665..20962017, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene ELK1, member of ETS oncogene family Neighboring gene RIKEN cDNA A230072C01 gene Neighboring gene zinc finger protein 182 Neighboring gene sperm acrosome associated 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome cycle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
protein UXT
Names
ubiquitously expressed transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418335.1NP_001405264.1  protein UXT isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671853
  2. NM_001418336.1NP_001405265.1  protein UXT isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671853
  3. NM_001418337.1NP_001405266.1  protein UXT isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671853
  4. NM_001418338.1NP_001405267.1  protein UXT isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671853
  5. NM_013840.4NP_038868.2  protein UXT isoform 1

    See identical proteins and their annotated locations for NP_038868.2

    Status: VALIDATED

    Source sequence(s)
    AL671853
    Consensus CDS
    CCDS30049.1
    UniProtKB/Swiss-Prot
    Q8CEJ2, Q9WTZ0
    UniProtKB/TrEMBL
    A0A6P5P4N1, A0A8C6HGP8
    Related
    ENSMUSP00000115342.2, ENSMUST00000123836.2
    Conserved Domains (1) summary
    cd00584
    Location:18147
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RNA

  1. NR_184722.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671853
  2. NR_184723.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671853
  3. NR_184724.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671853

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20817904..20828256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527602.4XP_006527665.1  protein UXT isoform X1

    Conserved Domains (1) summary
    cl09111
    Location:18111
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...