U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked [ Mus musculus (house mouse) ]

Gene ID: 22290, updated on 28-Dec-2022

Summary

Official Symbol
Utyprovided by MGI
Official Full Name
ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedprovided by MGI
Primary source
MGI:MGI:894810
See related
Ensembl:ENSMUSG00000068457 AllianceGenome:MGI:894810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hydb; mKIAA4057
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3-methyl-lysine-36 demethylase activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle cell contraction; and heterochromatin assembly. Part of protein-containing complex. Is expressed in several structures, including early conceptus; forelimb bud; genitourinary system; gut; and liver. Orthologous to human UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.8), CNS E14 (RPKM 1.7) and 18 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Uty in Genome Data Viewer
Location:
Y; Ypter
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1085187..1245787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1085187..1245773, complement)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene predicted gene 4017 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

Markers

Clone Names

  • KIAA4057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K27me2/H3K27me3 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone H3K36 demethylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone demethylase UTY
Names
[histone H3]-trimethyl-L-lysine(27) demethylase UTY
male-specific histocompatibility antigen H-YDB
ubiquitously transcribed TPR protein on the Y chromosome
ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
NP_001313611.1
NP_001313612.1
NP_033510.2
XP_006531647.1
XP_006531650.1
XP_006531652.1
XP_006531653.1
XP_011246883.1
XP_011246884.1
XP_011246885.1
XP_011246886.1
XP_011246887.1
XP_011246888.1
XP_011246891.1
XP_017174175.1
XP_017174176.1
XP_017174177.1
XP_017174178.1
XP_030107425.1
XP_036018082.1
XP_036018083.1
XP_036018084.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326682.1NP_001313611.1  histone demethylase UTY isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK142512, BC053061, BP764633, BP764956
    Consensus CDS
    CCDS85834.1
    UniProtKB/TrEMBL
    E9PWW8, Q3UQE8
    Related
    ENSMUSP00000114752.2, ENSMUST00000139365.8
    Conserved Domains (7) summary
    pfam02373
    Location:9441052
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:910974
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:279306
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:124157
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:311372
    TPR_11; TPR repeat
    pfam13424
    Location:274342
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:266297
    TPR_17; Tetratricopeptide repeat
  2. NM_001326683.1NP_001313612.1  histone demethylase UTY isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1
    Source sequence(s)
    AK142512, BC053061, BP764633, BP764956
    Consensus CDS
    CCDS85833.1
    UniProtKB/TrEMBL
    Q3UQE8
    Related
    ENSMUSP00000114910.2, ENSMUST00000154004.8
    Conserved Domains (7) summary
    pfam02373
    Location:882990
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:848912
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:217244
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6295
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:249310
    TPR_11; TPR repeat
    pfam13424
    Location:212280
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:204235
    TPR_17; Tetratricopeptide repeat
  3. NM_009484.3NP_033510.2  histone demethylase UTY isoform 1

    See identical proteins and their annotated locations for NP_033510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)
    Source sequence(s)
    AK043154, AK142512, BC053061, BP764633, BP764956
    Consensus CDS
    CCDS41216.1
    UniProtKB/TrEMBL
    G3X9F2, Q3UQE8, Q8C926
    Related
    ENSMUSP00000070012.8, ENSMUST00000069309.14
    Conserved Domains (7) summary
    pfam02373
    Location:9451053
    JmjC; JmjC domain, hydroxylase
    smart00558
    Location:911975
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    sd00006
    Location:280307
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:125158
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:312373
    TPR_11; TPR repeat
    pfam13424
    Location:275343
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:267298
    TPR_17; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    1085187..1245787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248585.4XP_011246887.1  histone demethylase UTY isoform X9

    Conserved Domains (4) summary
    smart00558
    Location:935999
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9691077
    JmjC; JmjC domain, hydroxylase
  2. XM_011248583.2XP_011246885.1  histone demethylase UTY isoform X5

    Conserved Domains (4) summary
    smart00558
    Location:916980
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:111378
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:285312
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9501058
    JmjC; JmjC domain, hydroxylase
  3. XM_036162190.1XP_036018083.1  histone demethylase UTY isoform X13

    Conserved Domains (4) summary
    smart00558
    Location:862926
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:97369
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:276303
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:8961004
    JmjC; JmjC domain, hydroxylase
  4. XM_036162189.1XP_036018082.1  histone demethylase UTY isoform X8

    Conserved Domains (4) summary
    smart00558
    Location:907971
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:97369
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:276303
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9411049
    JmjC; JmjC domain, hydroxylase
  5. XM_011248582.4XP_011246884.1  histone demethylase UTY isoform X4

    Conserved Domains (4) summary
    smart00558
    Location:931995
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:126393
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:300327
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9651073
    JmjC; JmjC domain, hydroxylase
  6. XM_030251565.2XP_030107425.1  histone demethylase UTY isoform X15

    Conserved Domains (4) summary
    smart00558
    Location:848912
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:38310
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:217244
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:882990
    JmjC; JmjC domain, hydroxylase
  7. XM_006531590.5XP_006531653.1  histone demethylase UTY isoform X12

    Related
    ENSMUSP00000115113.2, ENSMUST00000143286.8
    Conserved Domains (4) summary
    smart00558
    Location:863927
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:98370
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:277304
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:8971005
    JmjC; JmjC domain, hydroxylase
  8. XM_006531584.5XP_006531647.1  histone demethylase UTY isoform X7

    Conserved Domains (4) summary
    smart00558
    Location:908972
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:98370
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:277304
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9421050
    JmjC; JmjC domain, hydroxylase
  9. XM_011248581.4XP_011246883.1  histone demethylase UTY isoform X3

    Conserved Domains (4) summary
    smart00558
    Location:932996
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:127394
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:301328
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9661074
    JmjC; JmjC domain, hydroxylase
  10. XM_017318687.3XP_017174176.1  histone demethylase UTY isoform X2

    Conserved Domains (4) summary
    smart00558
    Location:934998
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:129396
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:303330
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9681076
    JmjC; JmjC domain, hydroxylase
  11. XM_017318688.3XP_017174177.1  histone demethylase UTY isoform X14

    Conserved Domains (4) summary
    smart00558
    Location:851915
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:41313
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:220247
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:885993
    JmjC; JmjC domain, hydroxylase
  12. XM_006531589.5XP_006531652.1  histone demethylase UTY isoform X11

    Conserved Domains (4) summary
    smart00558
    Location:866930
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:101373
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:280307
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9001008
    JmjC; JmjC domain, hydroxylase
  13. XM_006531587.5XP_006531650.1  histone demethylase UTY isoform X18

    Conserved Domains (4) summary
    smart00558
    Location:886950
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:101373
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:280307
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9201028
    JmjC; JmjC domain, hydroxylase
  14. XM_011248586.4XP_011246888.1  histone demethylase UTY isoform X10

    Conserved Domains (4) summary
    smart00558
    Location:890954
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9241032
    JmjC; JmjC domain, hydroxylase
  15. XM_011248584.4XP_011246886.1  histone demethylase UTY isoform X6

    Conserved Domains (4) summary
    smart00558
    Location:910974
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9441052
    JmjC; JmjC domain, hydroxylase
  16. XM_017318686.3XP_017174175.1  histone demethylase UTY isoform X1

    Conserved Domains (4) summary
    smart00558
    Location:935999
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:130397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304331
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:9691077
    JmjC; JmjC domain, hydroxylase
  17. XM_036162191.1XP_036018084.1  histone demethylase UTY isoform X17

    Conserved Domains (2) summary
    smart00558
    Location:448512
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02373
    Location:482590
    JmjC; JmjC domain, hydroxylase
  18. XM_017318689.2XP_017174178.1  histone demethylase UTY isoform X17

    Conserved Domains (2) summary
    smart00558
    Location:448512
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    pfam02373
    Location:482590
    JmjC; JmjC domain, hydroxylase
  19. XM_011248589.4XP_011246891.1  histone demethylase UTY isoform X16

    Conserved Domains (2) summary
    COG0457
    Location:130397
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:304331
    TPR; TPR repeat [structural motif]

RNA

  1. XR_004940595.1 RNA Sequence

  2. XR_879400.4 RNA Sequence

  3. XR_004940593.1 RNA Sequence

  4. XR_004940592.1 RNA Sequence

  5. XR_001782882.3 RNA Sequence

    Related
    ENSMUST00000154666.8
  6. XR_004940594.1 RNA Sequence