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Upp1 uridine phosphorylase 1 [ Mus musculus (house mouse) ]

Gene ID: 22271, updated on 8-Nov-2022

Summary

Official Symbol
Upp1provided by MGI
Official Full Name
uridine phosphorylase 1provided by MGI
Primary source
MGI:MGI:1097668
See related
Ensembl:ENSMUSG00000020407 AllianceGenome:MGI:1097668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Up; Upp; UPase; UdRPase
Summary
Enables deoxyuridine phosphorylase activity; thymidine phosphorylase activity; and uridine phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Located in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 191.4), small intestine adult (RPKM 74.3) and 4 other tissues See more
Orthologs
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Genomic context

See Upp1 in Genome Data Viewer
Location:
11; 11 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (9068008..9086170)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (9118008..9136170)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HUS1 checkpoint clamp component Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene predicted gene 11992 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C pseudogene Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables deoxyuridine phosphorylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables thymidine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uridine phosphorylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables uridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dCMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dTMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dUMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pyrimidine nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in uridine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uridine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within uridine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
uridine phosphorylase 1
Names
UPase 1
urdPase 1
NP_001152873.1
NP_001152874.1
NP_033503.2
XP_006514730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159401.1NP_001152873.1  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_001152873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, AV447018, BX527866
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000099063.3, ENSMUST00000101525.9
    Conserved Domains (1) summary
    cd17763
    Location:32306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2
  2. NM_001159402.1NP_001152874.1  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_001152874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, BX527866, CA493594
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000127473.2, ENSMUST00000164791.8
    Conserved Domains (1) summary
    cd17763
    Location:32306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2
  3. NM_009477.3NP_033503.2  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_033503.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK136474, AL118479, BX527866, CA536983
    Consensus CDS
    CCDS24432.1
    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Related
    ENSMUSP00000020677.2, ENSMUST00000020677.8
    Conserved Domains (1) summary
    cd17763
    Location:32306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    9068008..9086170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514667.3XP_006514730.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_006514730.1

    UniProtKB/Swiss-Prot
    P52624, Q8JZX0
    UniProtKB/TrEMBL
    Q5SUC8
    Conserved Domains (1) summary
    cd17763
    Location:32306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2