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TSPO2 translocator protein 2 [ Homo sapiens (human) ]

Gene ID: 222642, updated on 29-Jun-2021

Summary

Official Symbol
TSPO2provided by HGNC
Official Full Name
translocator protein 2provided by HGNC
Primary source
HGNC:HGNC:21256
See related
Ensembl:ENSG00000112212 MIM:619409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BZRPL1
Expression
Biased expression in bone marrow (RPKM 6.9) and testis (RPKM 0.2) See more
Orthologs
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Genomic context

See TSPO2 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41041344..41044337)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41010206..41012076)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929555 Neighboring gene Sharpr-MPRA regulatory region 12741 Neighboring gene unc-5 family C-terminal like Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene ADCY10 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129806, MGC129807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amino acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in enucleate erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translocator protein 2
Names
benzodiazapine receptor (peripheral)-like 1
peripheral-type benzodiazepine receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010873.3NP_001010873.1  translocator protein 2

    See identical proteins and their annotated locations for NP_001010873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI052224, AL031778, BC137565, BU655765, BU657409
    Consensus CDS
    CCDS34444.1
    UniProtKB/Swiss-Prot
    Q5TGU0
    Related
    ENSP00000362255.1, ENST00000373161.6
    Conserved Domains (1) summary
    pfam03073
    Location:10154
    TspO_MBR; TspO/MBR family
  2. NM_001159726.1NP_001153198.1  translocator protein 2

    See identical proteins and their annotated locations for NP_001153198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI052224, BC144710
    Consensus CDS
    CCDS34444.1
    UniProtKB/Swiss-Prot
    Q5TGU0
    Related
    ENSP00000419985.1, ENST00000470917.1
    Conserved Domains (1) summary
    pfam03073
    Location:10154
    TspO_MBR; TspO/MBR family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    41041344..41044337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514396.2XP_011512698.1  translocator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011512698.1

    UniProtKB/Swiss-Prot
    Q5TGU0
    Conserved Domains (1) summary
    pfam03073
    Location:10154
    TspO_MBR; TspO/MBR family
  2. XM_011514397.2XP_011512699.1  translocator protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011512699.1

    UniProtKB/Swiss-Prot
    Q5TGU0
    Conserved Domains (1) summary
    pfam03073
    Location:10154
    TspO_MBR; TspO/MBR family
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