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Uox urate oxidase [ Mus musculus (house mouse) ]

Gene ID: 22262, updated on 19-Mar-2019

Summary

Official Symbol
Uoxprovided by MGI
Official Full Name
urate oxidaseprovided by MGI
Primary source
MGI:MGI:98907
See related
Ensembl:ENSMUSG00000028186
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI663847
Expression
Biased expression in liver E18 (RPKM 291.5) and liver adult (RPKM 169.5) See more

Genomic context

See Uox in Genome Data Viewer
Location:
3 H2; 3 72.09 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (146597149..146631483)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (146260113..146294447)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 1 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 Neighboring gene ribosome production factor 1 homolog Neighboring gene deoxyribonuclease II beta Neighboring gene RIKEN cDNA 4930503B20 gene Neighboring gene predicted gene 16325 Neighboring gene predicted gene, 40169

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the Uox gene: The Uox gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
urate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
urate oxidase activity ISO
Inferred from Sequence Orthology
more info
 
urate oxidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
purine nucleobase metabolic process TAS
Traceable Author Statement
more info
PubMed 
urate catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
peroxisome TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009474.5NP_033500.1  uricase

    See identical proteins and their annotated locations for NP_033500.1

    Status: PROVISIONAL

    Source sequence(s)
    AC141632
    Consensus CDS
    CCDS17905.1
    UniProtKB/Swiss-Prot
    P25688
    UniProtKB/TrEMBL
    Q543J0
    Related
    ENSMUSP00000029837.7, ENSMUST00000029837.13
    Conserved Domains (2) summary
    cd00445
    Location:20297
    Uricase; Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the ...
    TIGR03383
    Location:15297
    urate_oxi; urate oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    146597149..146631483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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