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Ung uracil DNA glycosylase [ Mus musculus (house mouse) ]

Gene ID: 22256, updated on 26-Sep-2022

Summary

Official Symbol
Ungprovided by MGI
Official Full Name
uracil DNA glycosylaseprovided by MGI
Primary source
MGI:MGI:109352
See related
Ensembl:ENSMUSG00000029591 AllianceGenome:MGI:109352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UNG1; UNG2
Summary
Enables uracil DNA N-glycosylase activity. Acts upstream of or within isotype switching and somatic hypermutation of immunoglobulin genes. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 8.0), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ung in Genome Data Viewer
Location:
5; 5 F
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114268427..114277382)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114130366..114139321)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SV2 related protein Neighboring gene predicted gene 16108 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene forkhead box N4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uracil DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables uracil DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
enables uridine nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
uracil-DNA glycosylase
Names
UDG
NP_001035781.1
NP_035807.2
XP_006530347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040691.1NP_001035781.1  uracil-DNA glycosylase isoform a

    See identical proteins and their annotated locations for NP_001035781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC122282, AC129080, Y08975
    Consensus CDS
    CCDS39221.1
    UniProtKB/Swiss-Prot
    P97931, Q9JIW8
    Related
    ENSMUSP00000031587.7, ENSMUST00000031587.13
    Conserved Domains (2) summary
    PHA03201
    Location:12303
    PHA03201; uracil DNA glycosylase; Provisional
    TIGR00628
    Location:89298
    ung; uracil-DNA glycosylase
  2. NM_011677.2NP_035807.2  uracil-DNA glycosylase isoform b

    See identical proteins and their annotated locations for NP_035807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5'region, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC129080, AK168709, BB400166
    Consensus CDS
    CCDS19560.1
    UniProtKB/Swiss-Prot
    P97931
    UniProtKB/TrEMBL
    Q791V7
    Related
    ENSMUSP00000099644.5, ENSMUST00000102584.11
    Conserved Domains (1) summary
    TIGR00628
    Location:78287
    ung; uracil-DNA glycosylase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114268427..114277382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530284.5XP_006530347.1  uracil-DNA glycosylase isoform X1

    Conserved Domains (2) summary
    TIGR00628
    Location:89262
    ung; uracil-DNA glycosylase
    cd10027
    Location:145149
    UDG-F1-like; motif A [structural motif]