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Uncx UNC homeobox [ Mus musculus (house mouse) ]

Gene ID: 22255, updated on 17-Jan-2023

Summary

Official Symbol
Uncxprovided by MGI
Official Full Name
UNC homeoboxprovided by MGI
Primary source
MGI:MGI:108013
See related
Ensembl:ENSMUSG00000029546 AllianceGenome:MGI:108013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chx4; Uncx4.1
Summary
Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including animal organ development; common myeloid progenitor cell proliferation; and pattern specification process. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; paraxial mesenchyme; sensory organ; and skeleton. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 16.6), whole brain E14.5 (RPKM 10.7) and 3 other tissues See more
Orthologs
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Genomic context

See Uncx in Genome Data Viewer
Location:
5 G2; 5 78.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139529620..139533934)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139543865..139548179)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 2A Neighboring gene RIKEN cDNA 4930500L23 gene Neighboring gene predicted gene, 46926 Neighboring gene MICAL-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein unc-4 homolog
Names
Unc4.1 homeobox
homeobox protein Uncx4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013702.3NP_038730.1  homeobox protein unc-4 homolog

    See identical proteins and their annotated locations for NP_038730.1

    Status: VALIDATED

    Source sequence(s)
    AJ001116, AK082472, AV120135, BC051973
    Consensus CDS
    CCDS19813.1
    UniProtKB/Swiss-Prot
    O08934, Q78DU3
    Related
    ENSMUSP00000134067.3, ENSMUST00000172997.3
    Conserved Domains (1) summary
    pfam00046
    Location:112165
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139529620..139533934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254367.1XP_030110227.1  homeobox protein unc-4 homolog isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:99334
    PHA03247; large tegument protein UL36; Provisional
    PRK12270
    Location:243337
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
  2. XM_030254366.1XP_030110226.1  homeobox protein unc-4 homolog isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:99334
    PHA03247; large tegument protein UL36; Provisional
    PRK12270
    Location:243337
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit