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Unc13b unc-13 homolog B [ Mus musculus (house mouse) ]

Gene ID: 22249, updated on 24-Jun-2024

Summary

Official Symbol
Unc13bprovided by MGI
Official Full Name
unc-13 homolog Bprovided by MGI
Primary source
MGI:MGI:1342278
See related
Ensembl:ENSMUSG00000028456 AllianceGenome:MGI:1342278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc13a; Unc13h1; Unc13h2; Munc13-1; Munc13-2
Summary
Predicted to enable GTP-dependent protein binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including negative regulation of synaptic plasticity; positive regulation of defense response to bacterium; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; innervation; and regulation of short-term neuronal synaptic plasticity. Located in several cellular components, including calyx of Held; early phagosome; and glutamatergic synapse. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 6.9), CNS E14 (RPKM 6.8) and 23 other tissues See more
Orthologs
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Genomic context

See Unc13b in Genome Data Viewer
Location:
4 A5; 4 23.0 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43046193..43264873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43046193..43264873)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene STARR-positive B cell enhancer ABC_E6166 Neighboring gene stomatin (Epb7.2)-like 2 Neighboring gene STARR-seq mESC enhancer starr_10046 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene atos homolog B Neighboring gene STARR-seq mESC enhancer starr_10047 Neighboring gene predicted gene, 23709 Neighboring gene predicted gene, 25010 Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene STARR-seq mESC enhancer starr_10048 Neighboring gene STARR-seq mESC enhancer starr_10049 Neighboring gene predicted gene, 46851 Neighboring gene predicted gene, 46850 Neighboring gene RUN and SH3 domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-kinase phorbol ester receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in dense core granule docking IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dense core granule priming IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dense core granule priming ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innervation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular junction development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuronal dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic dense core vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic dense core granule exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptic vesicle docking IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle priming IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IC
Inferred by Curator
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein unc-13 homolog B
Names
UNC-13 homolog 1
munc13
unc13 homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081413.2NP_001074882.1  protein unc-13 homolog B isoform 2

    See identical proteins and their annotated locations for NP_001074882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one amino acid shorter than isoform 1.
    Source sequence(s)
    AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB245273, CB520764, CD351898, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839
    Consensus CDS
    CCDS38738.1
    UniProtKB/Swiss-Prot
    Q9Z1N9
    Related
    ENSMUSP00000128608.2, ENSMUST00000163653.8
    Conserved Domains (6) summary
    cd04027
    Location:612738
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14491568
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:490539
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9301032
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12751411
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  2. NM_001310758.1NP_001297687.1  protein unc-13 homolog B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter and has a distinct amino acid at the splice variant junction compared to isoform 1.
    Source sequence(s)
    AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB520764, CF746404, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839
    Consensus CDS
    CCDS80089.1
    UniProtKB/Swiss-Prot
    Q9Z1N9
    Related
    ENSMUSP00000078894.7, ENSMUST00000079978.13
    Conserved Domains (6) summary
    cd04027
    Location:600726
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14381557
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:478527
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9181021
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12641400
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  3. NM_001384106.1NP_001371035.1  protein unc-13 homolog B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AL672276, AL732504, AL772176
    UniProtKB/TrEMBL
    A0A140LJ69
    Related
    ENSMUSP00000147100.2, ENSMUST00000207569.2
    Conserved Domains (6) summary
    cd04027
    Location:32953421
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:41334252
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:36133716
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:39594095
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:31543235
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  4. NM_021468.3NP_067443.2  protein unc-13 homolog B isoform 1

    See identical proteins and their annotated locations for NP_067443.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL672276, BB612447, BI202627, BP758729, BQ572350, BU613335, BY741509, CB520764, CD351898, CJ053228, CK636958, CN459646, CO434486, CX568667, DV661336, EL605839
    Consensus CDS
    CCDS51161.1
    UniProtKB/Swiss-Prot
    A2AG43, B2RXT0, B2RXY6, Q6BCX2, Q9Z1N9
    Related
    ENSMUSP00000103586.3, ENSMUST00000107952.9
    Conserved Domains (6) summary
    cd04027
    Location:612738
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14501569
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:490539
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9301033
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12761412
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43046193..43264873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163977.1XP_036019870.1  protein unc-13 homolog B isoform X17

    Conserved Domains (5) summary
    cd04027
    Location:520646
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:13771496
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:838941
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:11841320
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:379460
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  2. XM_036163971.1XP_036019864.1  protein unc-13 homolog B isoform X8

    Conserved Domains (6) summary
    cd04027
    Location:625751
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14821601
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:9431046
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12891425
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:484565
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  3. XM_036163972.1XP_036019865.1  protein unc-13 homolog B isoform X9

    Conserved Domains (6) summary
    cd04027
    Location:623749
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14801599
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:9411044
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12871423
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:482563
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  4. XM_036163975.1XP_036019868.1  protein unc-13 homolog B isoform X14

    Conserved Domains (6) summary
    cd04027
    Location:623749
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14611580
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:9411044
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12871423
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:482563
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  5. XM_006537791.5XP_006537854.1  protein unc-13 homolog B isoform X10

    Conserved Domains (6) summary
    cd04027
    Location:614740
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14711590
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:492541
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9321033
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12781414
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  6. XM_017320116.3XP_017175605.1  protein unc-13 homolog B isoform X12

    Conserved Domains (6) summary
    cd04027
    Location:612738
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14691588
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:490539
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9301031
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12761412
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  7. XM_036163973.1XP_036019866.1  protein unc-13 homolog B isoform X11

    Conserved Domains (6) summary
    cd04027
    Location:613739
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14701589
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:9311034
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12771413
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:472553
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  8. XM_006537794.5XP_006537857.1  protein unc-13 homolog B isoform X15

    Conserved Domains (6) summary
    cd04027
    Location:602728
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14591578
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:480529
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9201021
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12661402
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  9. XM_006537795.5XP_006537858.1  protein unc-13 homolog B isoform X16

    UniProtKB/TrEMBL
    E9Q263
    Related
    ENSMUSP00000103587.3, ENSMUST00000107953.9
    Conserved Domains (6) summary
    cd04027
    Location:600726
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14571576
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:478527
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:9181019
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12641400
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
  10. XM_036163974.1XP_036019867.1  protein unc-13 homolog B isoform X13

    Conserved Domains (6) summary
    cd04027
    Location:612738
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:14681587
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:9301032
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:12751411
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:471552
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  11. XM_036163976.1XP_036019869.1  protein unc-13 homolog B isoform X17

    Conserved Domains (5) summary
    cd04027
    Location:520646
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:13771496
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:838941
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:11841320
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:379460
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
  12. XM_006537786.5XP_006537849.1  protein unc-13 homolog B isoform X1

    Conserved Domains (6) summary
    cd04027
    Location:9751101
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18321951
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:853902
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:12931394
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16391775
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  13. XM_006537790.5XP_006537853.1  protein unc-13 homolog B isoform X5

    Conserved Domains (6) summary
    cd04027
    Location:9751101
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18131932
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:853902
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:12931394
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16391775
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  14. XM_017320115.3XP_017175604.1  protein unc-13 homolog B isoform X1

    Conserved Domains (6) summary
    cd04027
    Location:9751101
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18321951
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:853902
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:12931394
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16391775
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  15. XM_006537789.5XP_006537852.1  protein unc-13 homolog B isoform X3

    UniProtKB/TrEMBL
    A0A140LHX5
    Related
    ENSMUSP00000146589.2, ENSMUST00000207708.2
    Conserved Domains (6) summary
    cd04027
    Location:9731099
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18301949
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:851900
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:12911392
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16371773
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  16. XM_006537788.5XP_006537851.1  protein unc-13 homolog B isoform X2

    Conserved Domains (6) summary
    cd04027
    Location:9751101
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18311950
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:853902
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:12931393
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16381774
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  17. XM_036163969.1XP_036019862.1  protein unc-13 homolog B isoform X6

    Conserved Domains (6) summary
    cd04027
    Location:9751101
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18121931
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:12931395
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16381774
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:834915
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  18. XM_036163968.1XP_036019861.1  protein unc-13 homolog B isoform X4

    Conserved Domains (6) summary
    cd04027
    Location:9731099
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18291948
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:12911393
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16361772
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:832913
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  19. XM_036163970.1XP_036019863.1  protein unc-13 homolog B isoform X7

    Conserved Domains (6) summary
    cd04027
    Location:9731099
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:18111930
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    pfam06292
    Location:12911394
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:16371773
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    cd20859
    Location:832913
    C1_Munc13-2-like; protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins
    cl09111
    Location:139219
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...