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LNX2 ligand of numb-protein X 2 [ Homo sapiens (human) ]

Gene ID: 222484, updated on 29-Mar-2020

Summary

Official Symbol
LNX2provided by HGNC
Official Full Name
ligand of numb-protein X 2provided by HGNC
Primary source
HGNC:HGNC:20421
See related
Ensembl:ENSG00000139517 MIM:609733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDZRN1
Expression
Ubiquitous expression in testis (RPKM 9.5), small intestine (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See LNX2 in Genome Data Viewer
Location:
13q12.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (27545913..27621106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28120048..28194720, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIA Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene RNA, U6 small nuclear 63, pseudogene Neighboring gene RNA polymerase I and III subunit D Neighboring gene uncharacterized LOC105370128 Neighboring gene nucleophosmin 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.
NHGRI GWA Catalog
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ligand of numb-protein X 2 (LNX2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12933, FLJ23932, FLJ38000, MGC46315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ligand of Numb protein X 2
Names
PDZ domain containing ring finger 1
PDZ domain-containing RING finger protein 1
numb-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153371.4NP_699202.1  ligand of Numb protein X 2

    See identical proteins and their annotated locations for NP_699202.1

    Status: VALIDATED

    Source sequence(s)
    AK022995, BC036755, DB220129, DN990012
    Consensus CDS
    CCDS9323.1
    UniProtKB/Swiss-Prot
    Q8N448
    Related
    ENSP00000325929.3, ENST00000316334.5
    Conserved Domains (3) summary
    smart00228
    Location:230316
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:599683
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:4589
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    27545913..27621106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020434.1XP_016875923.1  ligand of Numb protein X 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8N448
    Related
    ENSP00000497224.1, ENST00000649248.1
    Conserved Domains (3) summary
    smart00228
    Location:230316
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:599683
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:4589
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
  2. XM_011534995.2XP_011533297.1  ligand of Numb protein X 2 isoform X2

    Conserved Domains (3) summary
    smart00184
    Location:5086
    RING; Ring finger
    smart00228
    Location:230299
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:476560
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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