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Uck1 uridine-cytidine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 22245, updated on 1-Mar-2024

Summary

Official Symbol
Uck1provided by MGI
Official Full Name
uridine-cytidine kinase 1provided by MGI
Primary source
MGI:MGI:98904
See related
Ensembl:ENSMUSG00000002550 AllianceGenome:MGI:98904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
URK1; Umpk
Summary
Enables uridine kinase activity. Involved in UMP salvage. Predicted to be active in cytosol. Is expressed in nervous system; respiratory system; and urinary system. Orthologous to human UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 75.9), adrenal adult (RPKM 70.6) and 28 other tissues See more
Orthologs
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Genomic context

See Uck1 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32145014..32150117, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32255002..32260105, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2B Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10094 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9197 Neighboring gene SWI5 recombination repair homolog (yeast)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytidine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uridine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CTP salvage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within UMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within UMP salvage IC
Inferred by Curator
more info
PubMed 
involved_in UMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uridine-cytidine kinase 1
Names
cytidine monophosphokinase 1
uridine monophosphate kinase
uridine monophosphokinase 1
NP_001365720.1
NP_001365721.1
NP_035805.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378791.1NP_001365720.1  uridine-cytidine kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL808027
    UniProtKB/Swiss-Prot
    P52623
    Conserved Domains (1) summary
    cd02023
    Location:31254
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  2. NM_001378792.1NP_001365721.1  uridine-cytidine kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL808027
    UniProtKB/Swiss-Prot
    P52623
    Conserved Domains (1) summary
    cd02023
    Location:12187
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  3. NM_011675.2NP_035805.2  uridine-cytidine kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK132100, BY338721, CJ194826, L31783
    Consensus CDS
    CCDS15909.2
    UniProtKB/Swiss-Prot
    P52623
    UniProtKB/TrEMBL
    A2AN37
    Related
    ENSMUSP00000002625.9, ENSMUST00000002625.15
    Conserved Domains (2) summary
    COG0572
    Location:24238
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:31236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32145014..32150117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)