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Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) [ Mus musculus (house mouse) ]

Gene ID: 22228, updated on 1-Mar-2024

Summary

Official Symbol
Ucp2provided by MGI
Official Full Name
uncoupling protein 2 (mitochondrial, proton carrier)provided by MGI
Primary source
MGI:MGI:109354
See related
Ensembl:ENSMUSG00000033685 AllianceGenome:MGI:109354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCPH; UCP 2; Slc25a8
Summary
Predicted to enable oxidative phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 802.8), duodenum adult (RPKM 693.5) and 19 other tissues See more
Orthologs
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Genomic context

See Ucp2 in Genome Data Viewer
Location:
7 E2; 7 54.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100142565..100148832)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100493337..100499629)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene predicted gene 10603 Neighboring gene uncoupling protein 3 (mitochondrial, proton carrier) Neighboring gene STARR-positive B cell enhancer mm9_chr7:107641658-107641958 Neighboring gene STARR-positive B cell enhancer ABC_E2244 Neighboring gene STARR-seq mESC enhancer starr_19669 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene predicted gene, 39058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables malate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables oxaloacetate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphate ion uniporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables secondary active sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in C4-dicarboxylate transport ISO
Inferred from Sequence Orthology
more info
 
involved_in adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to superoxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dicarboxylate carrier SLC25A8
Names
mitochondrial uncoupling protein 2
solute carrier family 25 member 8
uncoupling protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417452.1NP_001404381.1  dicarboxylate carrier SLC25A8

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
  2. NM_001417453.1NP_001404382.1  dicarboxylate carrier SLC25A8

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
    Related
    ENSMUSP00000146337.2, ENSMUST00000207748.2
  3. NM_001417454.1NP_001404383.1  dicarboxylate carrier SLC25A8

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
  4. NM_001417455.1NP_001404384.1  dicarboxylate carrier SLC25A8

    Status: VALIDATED

    Source sequence(s)
    AC117215
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
  5. NM_011671.6NP_035801.3  dicarboxylate carrier SLC25A8

    See identical proteins and their annotated locations for NP_035801.3

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21498.1
    UniProtKB/Swiss-Prot
    O88285, P70406
    UniProtKB/TrEMBL
    Q549J5, Q8CBU0, Q9R246
    Related
    ENSMUSP00000120967.2, ENSMUST00000126534.8
    Conserved Domains (1) summary
    pfam00153
    Location:115206
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_184451.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215
  2. NR_184452.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100142565..100148832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)