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Sumo1 small ubiquitin-like modifier 1 [ Mus musculus (house mouse) ]

Gene ID: 22218, updated on 5-Sep-2021

Summary

Official Symbol
Sumo1provided by MGI
Official Full Name
small ubiquitin-like modifier 1provided by MGI
Primary source
MGI:MGI:1197010
See related
Ensembl:ENSMUSG00000026021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI; SE; Ubl; GMP1; PIC1; SMT3; Ubl1; SMTP3; Smt3C; SMT3H3; SUMO-1; SENTRIN
Expression
Broad expression in CNS E11.5 (RPKM 56.9), CNS E14 (RPKM 40.0) and 21 other tissues See more
Orthologs
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Genomic context

See Sumo1 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59678593..59709993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59639434..59670834, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (59696278..59727678, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 973 Neighboring gene predicted gene, 39648 Neighboring gene predicted gene, 33833 Neighboring gene NOP58 ribonucleoprotein Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene predicted gene, 26293

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103203

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within PML body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of transcription by transcription factor localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to nuclear pore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body TAS
Traceable Author Statement
more info
PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
located_in XY body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
small ubiquitin-related modifier 1
Names
SMT3 homolog 3
SMT3 suppressor of mif two 3 homolog 1
SUMO-1 related peptidase
ubiquitin-homology domain protein PIC1
ubiquitin-like 1
ubiquitin-like protein SMT3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009460.2NP_033486.1  small ubiquitin-related modifier 1

    See identical proteins and their annotated locations for NP_033486.1

    Status: VALIDATED

    Source sequence(s)
    AK159366, BC082566, BE691755, BY242724
    Consensus CDS
    CCDS35586.1
    UniProtKB/Swiss-Prot
    P63166
    Related
    ENSMUSP00000088935.3, ENSMUST00000091374.9
    Conserved Domains (1) summary
    cd16114
    Location:2196
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59678593..59709993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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