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PRR15 proline rich 15 [ Homo sapiens (human) ]

Gene ID: 222171, updated on 17-Sep-2024

Summary

Official Symbol
PRR15provided by HGNC
Official Full Name
proline rich 15provided by HGNC
Primary source
HGNC:HGNC:22310
See related
Ensembl:ENSG00000176532 MIM:618344; AllianceGenome:HGNC:22310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in colon (RPKM 29.0), small intestine (RPKM 15.6) and 6 other tissues See more
Orthologs
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Genomic context

See PRR15 in Genome Data Viewer
Location:
7p14.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29563835..29567295)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29701617..29705075)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29603451..29606911)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:29327971-29328748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343002-29343502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29343503-29344003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29349448-29350016 Neighboring gene NANOG hESC enhancer GRCh37_chr7:29364906-29365431 Neighboring gene MPRA-validated peak6458 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29414107-29414613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456733-29457232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29456231-29456732 Neighboring gene PRR15 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29605074-29605937 Neighboring gene GTF3C6 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 12919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29688411-29689013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29689014-29689615 Neighboring gene TMSB4X pseudogene 3 Neighboring gene MIR550A3 host gene Neighboring gene microRNA 550a-3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329996.2NP_001316925.1  proline-rich protein 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC007255
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13109
    ATAD4; ATPase family AAA domain containing 4
  2. NM_001329997.1NP_001316926.1  proline-rich protein 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC007255
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13109
    ATAD4; ATPase family AAA domain containing 4
  3. NM_175887.3NP_787083.1  proline-rich protein 15

    See identical proteins and their annotated locations for NP_787083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC029131
    Consensus CDS
    CCDS5421.1
    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Related
    ENSP00000317836.2, ENST00000319694.3
    Conserved Domains (1) summary
    pfam15321
    Location:13109
    ATAD4; ATPase family AAA domain containing 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    29563835..29567295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515199.2XP_011513501.1  proline-rich protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011513501.1

    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13109
    ATAD4; ATPase family AAA domain containing 4
  2. XM_011515198.2XP_011513500.1  proline-rich protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011513500.1

    UniProtKB/Swiss-Prot
    Q8IV56
    UniProtKB/TrEMBL
    A4D1A1
    Conserved Domains (1) summary
    pfam15321
    Location:13109
    ATAD4; ATPase family AAA domain containing 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    29701617..29705075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357569.1XP_054213544.1  proline-rich protein 15 isoform X1

  2. XM_054357568.1XP_054213543.1  proline-rich protein 15 isoform X1