U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ube2b ubiquitin-conjugating enzyme E2B [ Mus musculus (house mouse) ]

Gene ID: 22210, updated on 8-Feb-2024

Summary

Official Symbol
Ube2bprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Bprovided by MGI
Primary source
MGI:MGI:102944
See related
Ensembl:ENSMUSG00000020390 AllianceGenome:MGI:102944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HR6B; E214K; Rad6b; mHR6B; E2-14k
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; positive regulation of reciprocal meiotic recombination; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 40.4), heart adult (RPKM 37.3) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ube2b in Genome Data Viewer
Location:
11 B1.3; 11 31.82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51875965..51894972, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51985138..52004145, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene predicted gene, 26061 Neighboring gene STARR-seq mESC enhancer starr_29438 Neighboring gene cyclin dependent kinase like 3 Neighboring gene STARR-seq mESC enhancer starr_29439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51879429-51879612 Neighboring gene STARR-positive B cell enhancer ABC_E8875 Neighboring gene STARR-positive B cell enhancer ABC_E10674 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chiasma assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within leptotene IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of post-translational protein modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postreplication repair ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HULC complex ISO
Inferred from Sequence Orthology
more info
 
located_in XY body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 B
Names
E2 ubiquitin-conjugating enzyme B
RAD6 homolog B
ubiquitin carrier protein B
ubiquitin-conjugating enzyme E2B, RAD6 homology
ubiquitin-protein ligase B
NP_001349614.1
NP_001349615.1
NP_033484.3
XP_011247269.1
XP_030101785.1
XP_030101786.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362685.1NP_001349614.1  ubiquitin-conjugating enzyme E2 B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL669920, CF951907
    Consensus CDS
    CCDS24664.1
    UniProtKB/Swiss-Prot
    P63147, Q3UGS2
    UniProtKB/TrEMBL
    A2RSE4, Q3TUV9
    Related
    ENSMUSP00000104714.2, ENSMUST00000109086.8
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_001362686.1NP_001349615.1  ubiquitin-conjugating enzyme E2 B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669920
    Conserved Domains (1) summary
    pfam00179
    Location:8115
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_009458.5NP_033484.3  ubiquitin-conjugating enzyme E2 B isoform 1

    See identical proteins and their annotated locations for NP_033484.3

    Status: VALIDATED

    Source sequence(s)
    AK147785, AK169229, AL669920, BE944184
    Consensus CDS
    CCDS24664.1
    UniProtKB/Swiss-Prot
    P63147, Q3UGS2
    UniProtKB/TrEMBL
    A2RSE4, Q3TUV9
    Related
    ENSMUSP00000020657.7, ENSMUST00000020657.13
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51875965..51894972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245925.1XP_030101785.1  ubiquitin-conjugating enzyme E2 B isoform X1

    UniProtKB/Swiss-Prot
    P63147, Q3UGS2
    UniProtKB/TrEMBL
    A2RSE4, Q3TUV9
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme
  2. XM_011248967.2XP_011247269.1  ubiquitin-conjugating enzyme E2 B isoform X1

    See identical proteins and their annotated locations for XP_011247269.1

    UniProtKB/Swiss-Prot
    P63147, Q3UGS2
    UniProtKB/TrEMBL
    A2RSE4, Q3TUV9
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme
  3. XM_030245926.1XP_030101786.1  ubiquitin-conjugating enzyme E2 B isoform X2

    Conserved Domains (1) summary
    pfam00179
    Location:8115
    UQ_con; Ubiquitin-conjugating enzyme