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TMED4 transmembrane p24 trafficking protein 4 [ Homo sapiens (human) ]

Gene ID: 222068, updated on 1-Jun-2020

Summary

Official Symbol
TMED4provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 4provided by HGNC
Primary source
HGNC:HGNC:22301
See related
Ensembl:ENSG00000158604 MIM:612038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNLF; ERS25; p24a3; GMP25iso; p24alpha3
Expression
Ubiquitous expression in thyroid (RPKM 37.8), small intestine (RPKM 27.8) and 25 other tissues See more
Orthologs

Genomic context

See TMED4 in Genome Data Viewer
Location:
7p13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44577894..44582295, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44617493..44621881, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NPC1 like intracellular cholesterol transporter 1 Neighboring gene DEAD-box helicase 56 Neighboring gene oxoglutarate dehydrogenase Neighboring gene OGDH intron CAGE-defined high expression enhancer Neighboring gene zinc finger MIZ-type containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with transmembrane emp24 protein transport domain containing 4 (TMED4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DDX56

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 4
Names
endoplasmic reticulum stress-response protein 25 kDa
p24 family protein alpha-3
putative NF-kappa-B-activating protein 156
putative NFkB activating protein HNLF
transmembrane emp24 protein transport domain containing 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303058.1NP_001289987.1  transmembrane emp24 domain-containing protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001289987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK074557, BM857430, DA419871
    Consensus CDS
    CCDS78227.1
    UniProtKB/Swiss-Prot
    Q7Z7H5
    Related
    ENSP00000417443.1, ENST00000481238.1
    Conserved Domains (1) summary
    pfam01105
    Location:29179
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  2. NM_001303059.2NP_001289988.1  transmembrane emp24 domain-containing protein 4 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC004938, BC035467, BP872004, BX647965, DA419871
    Consensus CDS
    CCDS78226.1
    UniProtKB/TrEMBL
    F8W7F7
    Related
    ENSP00000289577.5, ENST00000289577.9
    Conserved Domains (1) summary
    pfam01105
    Location:29173
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  3. NM_001303060.1NP_001289989.1  transmembrane emp24 domain-containing protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the both the 5' and 3' exon structure, compared to variant 1, and initiates translation at a downstream start codon. The encoded isoform (4) has a shorter N-terminus and distinct C-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AK074557, BC025705, BM857430, DA419871
    UniProtKB/Swiss-Prot
    Q7Z7H5
    Related
    ENST00000477639.5
    Conserved Domains (1) summary
    pfam01105
    Location:7120
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  4. NM_001303061.2NP_001289990.1  transmembrane emp24 domain-containing protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001289990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1. Variants 5 and 6 encode the same isoform (5).
    Source sequence(s)
    AC004938, AL602839, BC035467, BX647965, DA419871
    Conserved Domains (1) summary
    pfam01105
    Location:7163
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  5. NM_001303062.2NP_001289991.1  transmembrane emp24 domain-containing protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001289991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate segment in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1. Variants 5 and 6 encode the same isoform (5).
    Source sequence(s)
    AC004938, BC025705, BC035467, BX461603, BX647965, DA419871
    Conserved Domains (1) summary
    pfam01105
    Location:7163
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  6. NM_182547.4NP_872353.2  transmembrane emp24 domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_872353.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004938, BC035467, BC052641, BX647965, DA419871
    Consensus CDS
    CCDS5493.1
    UniProtKB/Swiss-Prot
    Q7Z7H5
    Related
    ENSP00000404042.2, ENST00000457408.7
    Conserved Domains (1) summary
    pfam01105
    Location:29222
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44577894..44582295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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