Format

Send to:

Choose Destination

VSTM2A V-set and transmembrane domain containing 2A [ Homo sapiens (human) ]

Gene ID: 222008, updated on 12-Oct-2019

Summary

Official Symbol
VSTM2Aprovided by HGNC
Official Full Name
V-set and transmembrane domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:28499
See related
Ensembl:ENSG00000170419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VSTM2
Expression
Biased expression in brain (RPKM 3.8), prostate (RPKM 1.6) and 4 other tissues See more
Orthologs

Genomic context

See VSTM2A in Genome Data Viewer
Location:
7p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (54542064..54571080)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (54610019..54636948)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1445 Neighboring gene solute carrier family 25 member 5 pseudogene 3 Neighboring gene VSTM2A overlapping transcript 1 Neighboring gene RNA, U6 small nuclear 1125, pseudogene Neighboring gene ribosomal protein L31 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to BMP stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of white fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
V-set and transmembrane domain-containing protein 2A
Names
V-set and transmembrane domain containing 2
hypothetical protein MGC33530

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301009.1NP_001287938.1  V-set and transmembrane domain-containing protein 2A isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region due to the use of an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BI458531, BI752069, BI755592, BI758069, BQ639021, DN991972, EY892386, R40993
    Consensus CDS
    CCDS75604.1
    UniProtKB/TrEMBL
    F8W8J5
    Related
    ENSP00000384103.3, ENST00000402613.3
    Conserved Domains (2) summary
    smart00410
    Location:33148
    IG_like; Immunoglobulin like
    cl11960
    Location:33138
    Ig; Immunoglobulin domain
  2. NM_001317843.2NP_001304772.1  V-set and transmembrane domain-containing protein 2A isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks one exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC069313, BC028404, BI553644, BI755592
    Consensus CDS
    CCDS83185.1
    UniProtKB/Swiss-Prot
    Q8TAG5
    Related
    ENSP00000303108.3, ENST00000302287.7
    Conserved Domains (2) summary
    smart00410
    Location:33148
    IG_like; Immunoglobulin like
    cl11960
    Location:33138
    Ig; Immunoglobulin domain
  3. NM_182546.3NP_872352.2  V-set and transmembrane domain-containing protein 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_872352.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    BI458531, BI752069, BI754879, BI755592, BQ639021, DN991972, EY892386, R40993
    Consensus CDS
    CCDS5512.2
    UniProtKB/Swiss-Prot
    Q8TAG5
    Related
    ENSP00000384967.3, ENST00000407838.7
    Conserved Domains (2) summary
    smart00410
    Location:33148
    IG_like; Immunoglobulin like
    cl11960
    Location:33138
    Ig; Immunoglobulin domain

RNA

  1. NR_133927.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons, uses an alternate 5'-terminal exon, and an alternate splice site in the 3'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI340204, BI458531, BI667944, BX451729, EY892386, R40993

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    54542064..54571080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715666.3XP_006715729.1  V-set and transmembrane domain-containing protein 2A isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:33148
    IG_like; Immunoglobulin like
    cl11960
    Location:33138
    Ig; Immunoglobulin domain
  2. XM_006715665.3XP_006715728.1  V-set and transmembrane domain-containing protein 2A isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:33148
    IG_like; Immunoglobulin like
    cl11960
    Location:33138
    Ig; Immunoglobulin domain
  3. XM_017011841.1XP_016867330.1  V-set and transmembrane domain-containing protein 2A isoform X1

Support Center