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FCN2 ficolin 2 [ Homo sapiens (human) ]

Gene ID: 2220, updated on 7-Dec-2018

Summary

Official Symbol
FCN2provided by HGNC
Official Full Name
ficolin 2provided by HGNC
Primary source
HGNC:HGNC:3624
See related
Ensembl:ENSG00000160339 MIM:601624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P35; FCNL; EBP-37; ficolin-2
Summary
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 10.3), adrenal (RPKM 1.6) and 2 other tissues See more
Orthologs

Genomic context

See FCN2 in Genome Data Viewer
Location:
9q34.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (134864062..134890506)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137772658..137779366)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101448202 Neighboring gene microRNA 3689e Neighboring gene microRNA 3689f Neighboring gene ficolin 1 Neighboring gene uncharacterized LOC105376314

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication is inhibited by exogenous addition of FCN2 (ficolin-2) in TZM-bl cells PubMed
HIV-1 NL4-3 and JRFL upregulate expression of FCN2 (ficolin-2) in HEK293T cells PubMed
Clinical samples from HIV-1 infected patients have upregulated levels of FCN2 (ficolin-2) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) interacts with FCN2 (ficolin-2) on the surface of gp120 expressing 293T cells PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of ficolin (collagen/fibrinogen domain containing lectin) 2 (FCN2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
  • Creation of C4 and C2 activators, organism-specific biosystem (from REACTOME)
    Creation of C4 and C2 activators, organism-specific biosystemTwo pathways lead to a complex capable of activating C4 and C2.The classical pathway is triggered by activation of the C1-complex, which consists of hexameric molecule C1q and a tetramer comprising t...
  • Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystem (from REACTOME)
    Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystemFicolins are recognition molecules in the lectin pathway of complement activation. Three types of ficolin have been identified in humans: M-ficolin (ficolin-1, FCN1), L-ficolin (ficolin-2, FCN2) and ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Initial triggering of complement, organism-specific biosystem (from REACTOME)
    Initial triggering of complement, organism-specific biosystemComplement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by t...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lectin pathway of complement activation, organism-specific biosystem (from REACTOME)
    Lectin pathway of complement activation, organism-specific biosystemActivation of the lectin pathway (LP) is initiated by Mannose-binding lectin (MBL), the hetero-complex CL-LK formed from COLEC11 (Collectin liver 1, CL-L1) and COLEC10 (Collectin kidney 1, CL-K1), an...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mannan binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
complement activation TAS
Traceable Author Statement
more info
 
complement activation, lectin pathway IDA
Inferred from Direct Assay
more info
PubMed 
complement activation, lectin pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
opsonization IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ficolin-2
Names
37 kDa elastin-binding protein
L-ficolin
collagen/fibrinogen domain-containing protein 2
ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
ficolin B
ficolin-beta
serum lectin p35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011649.1 RefSeqGene

    Range
    5001..11709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004108.3NP_004099.2  ficolin-2 isoform a precursor

    See identical proteins and their annotated locations for NP_004099.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SV0) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AI052239, AL603650, BC069572
    Consensus CDS
    CCDS6983.1
    UniProtKB/Swiss-Prot
    Q15485
    Related
    ENSP00000291744.6, ENST00000291744.10
    Conserved Domains (1) summary
    cd00087
    Location:102312
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_015837.2NP_056652.1  ficolin-2 isoform b precursor

    See identical proteins and their annotated locations for NP_056652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SV1) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AI052239, BC069572
    UniProtKB/Swiss-Prot
    Q15485
    Related
    ENSP00000291741.5, ENST00000350339.3
    Conserved Domains (1) summary
    cd00087
    Location:64274
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    134864062..134890506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518392.3XP_011516694.1  ficolin-2 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:91301
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. XM_006717015.4XP_006717078.1  ficolin-2 isoform X2

    Conserved Domains (1) summary
    cd00087
    Location:53263
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015838.1: Suppressed sequence

    Description
    NM_015838.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_015839.1: Suppressed sequence

    Description
    NM_015839.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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