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DAGLB diacylglycerol lipase beta [ Homo sapiens (human) ]

Gene ID: 221955, updated on 22-Aug-2020

Summary

Official Symbol
DAGLBprovided by HGNC
Official Full Name
diacylglycerol lipase betaprovided by HGNC
Primary source
HGNC:HGNC:28923
See related
Ensembl:ENSG00000164535 MIM:614016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCCR13L; DAGLBETA
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), brain (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See DAGLB in Genome Data Viewer
Location:
7p22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (6409129..6447954, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6448747..6487837, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 73 Neighboring gene Rac family small GTPase 1 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2 Neighboring gene ribosomal protein L31 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with diacylglycerol lipase, beta (DAGLB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: KDELR2

Homology

Clone Names

  • FLJ33624, FLJ33909, FLJ45532

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
endocannabinoid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde trans-synaptic signaling by endocannabinoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
diacylglycerol lipase-beta
Names
DAGL-beta
DGL-beta
PUFA-specific triacylglycerol lipase
sn1-specific diacylglycerol lipase beta
NP_001136408.1
NP_631918.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142936.2NP_001136408.1  diacylglycerol lipase-beta isoform 2

    See identical proteins and their annotated locations for NP_001136408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate internal exons, compared to variant 1, resulting in a translational frameshift in the mid coding region. The encoded isoform (2) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AK075128, AK298955, DC304654, F17444
    Consensus CDS
    CCDS47536.1
    UniProtKB/Swiss-Prot
    Q8NCG7
    Related
    ENSP00000391171.2, ENST00000425398.6
    Conserved Domains (1) summary
    cd00519
    Location:214378
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  2. NM_139179.4NP_631918.3  diacylglycerol lipase-beta isoform 1

    See identical proteins and their annotated locations for NP_631918.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK075128, DC304654, F17444
    Consensus CDS
    CCDS5350.1
    UniProtKB/Swiss-Prot
    Q8NCG7
    Related
    ENSP00000297056.6, ENST00000297056.11
    Conserved Domains (1) summary
    cd00519
    Location:274507
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    6409129..6447954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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