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FOXK1 forkhead box K1 [ Homo sapiens (human) ]

Gene ID: 221937, updated on 6-Jan-2019

Summary

Official Symbol
FOXK1provided by HGNC
Official Full Name
forkhead box K1provided by HGNC
Primary source
HGNC:HGNC:23480
See related
Ensembl:ENSG00000164916 MIM:616302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXK1L
Expression
Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See FOXK1 in Genome Data Viewer
Location:
7p22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (4642284..4771443)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4721930..4811074)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 3 subfamily A member 54, pseudogene Neighboring gene uncharacterized LOC105375133 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 2 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene microRNA 4656 Neighboring gene Rap associating with DIL domain Neighboring gene small nucleolar RNA, C/D box 165

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14977

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
forkhead box protein K1
Names
MNF
myocyte nuclear factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037165.2NP_001032242.1  forkhead box protein K1

    See identical proteins and their annotated locations for NP_001032242.1

    Status: VALIDATED

    Source sequence(s)
    AC072054, AC092428, AC092610
    Consensus CDS
    CCDS34591.1
    UniProtKB/Swiss-Prot
    P85037
    Related
    ENSP00000328720.4, ENST00000328914.4
    Conserved Domains (3) summary
    COG1716
    Location:102204
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:110203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:305391
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    4642284..4771443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515191.3XP_011513493.1  forkhead box protein K1 isoform X1

    See identical proteins and their annotated locations for XP_011513493.1

    UniProtKB/Swiss-Prot
    P85037
    Conserved Domains (2) summary
    pfam00250
    Location:142227
    Forkhead; Forkhead domain
    pfam05110
    Location:250334
    AF-4; AF-4 proto-oncoprotein
  2. XM_024446685.1XP_024302453.1  forkhead box protein K1 isoform X1

    Conserved Domains (2) summary
    pfam00250
    Location:142227
    Forkhead; Forkhead domain
    pfam05110
    Location:250334
    AF-4; AF-4 proto-oncoprotein
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