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FOXK1 forkhead box K1 [ Homo sapiens (human) ]

Gene ID: 221937, updated on 9-Jun-2024

Summary

Official Symbol
FOXK1provided by HGNC
Official Full Name
forkhead box K1provided by HGNC
Primary source
HGNC:HGNC:23480
See related
Ensembl:ENSG00000164916 MIM:616302; AllianceGenome:HGNC:23480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXK1L
Summary
Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See FOXK1 in Genome Data Viewer
Location:
7p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4682295..4771442)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4799494..4888656)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4721926..4811073)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375133 Neighboring gene MPRA-validated peak6348 silencer Neighboring gene endogenous retrovirus group K member 6 Env polyprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4643917-4644418 Neighboring gene Sharpr-MPRA regulatory region 9979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17897 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:4704492-4704666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:4720927-4721427 Neighboring gene Sharpr-MPRA regulatory region 11841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4722783-4723310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4739232-4739732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4742083-4742842 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4744443-4745084 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4745727-4746368 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4746369-4747010 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4747011-4747652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4747653-4748294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4748937-4749577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4750899-4751431 Neighboring gene uncharacterized LOC124901581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4763724-4764310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4776642-4777196 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:4777977-4779176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4779416-4779969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4779970-4780524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4789475-4789974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4793383-4793937 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:4800052-4801251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4813996-4814672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4814673-4815349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:4832559-4833233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4848405-4848904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:4847903-4848404 Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene microRNA 4656 Neighboring gene Rap associating with DIL domain Neighboring gene small nucleolar RNA, C/D box 165

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14977

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box protein K1
Names
MNF
myocyte nuclear factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037165.2NP_001032242.1  forkhead box protein K1

    See identical proteins and their annotated locations for NP_001032242.1

    Status: VALIDATED

    Source sequence(s)
    AC072054, AC092428, AC092610
    Consensus CDS
    CCDS34591.1
    UniProtKB/Swiss-Prot
    P85037
    Related
    ENSP00000328720.4, ENST00000328914.5
    Conserved Domains (3) summary
    COG1716
    Location:102204
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:110203
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00250
    Location:305391
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    4682295..4771442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    4799494..4888656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)