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PPP1R35 protein phosphatase 1 regulatory subunit 35 [ Homo sapiens (human) ]

Gene ID: 221908, updated on 5-Jul-2025
Official Symbol
PPP1R35provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 35provided by HGNC
Primary source
HGNC:HGNC:28320
See related
Ensembl:ENSG00000160813 MIM:618937; AllianceGenome:HGNC:28320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf47
Summary
Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis (RPKM 18.3), spleen (RPKM 14.1) and 25 other tissues See more
Orthologs
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See PPP1R35 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100435282..100436698, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101675360..101676755, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100032905..100034120, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger CW-type and PWWP domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18433 Neighboring gene methylphosphate capping enzyme Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100034207-100034710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100034711-100035213 Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:100044099-100044599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18434 Neighboring gene TSC22D4-C7orf61 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100054725-100054887 Neighboring gene sperm acrosome developmental regulator Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100069322-100070108 Neighboring gene TSC22 domain family member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100070109-100070893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26368

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC22793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in notochord morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in notochord morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of centriole elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of centriole elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein phosphatase 1 regulatory subunit 35
Names
UPF0683 protein C7orf47

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346938.2NP_001333867.1  protein phosphatase 1 regulatory subunit 35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC092849
  2. NM_145030.4NP_659467.1  protein phosphatase 1 regulatory subunit 35 isoform 1

    See identical proteins and their annotated locations for NP_659467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092849, AI433518, BC026269, BI752874
    Consensus CDS
    CCDS5694.1
    UniProtKB/Swiss-Prot
    A4D2C5, Q8TAP8
    Related
    ENSP00000292330.2, ENST00000292330.3
    Conserved Domains (1) summary
    pfam15503
    Location:104248
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100435282..100436698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515914.2XP_011514216.1  protein phosphatase 1 regulatory subunit 35 isoform X1

    Conserved Domains (1) summary
    pfam15503
    Location:34178
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101675360..101676755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357536.1XP_054213511.1  protein phosphatase 1 regulatory subunit 35 isoform X1