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PPP1R35 protein phosphatase 1 regulatory subunit 35 [ Homo sapiens (human) ]

Gene ID: 221908, updated on 5-Aug-2022

Summary

Official Symbol
PPP1R35provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 35provided by HGNC
Primary source
HGNC:HGNC:28320
See related
Ensembl:ENSG00000160813 MIM:618937; AllianceGenome:HGNC:28320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf47
Summary
Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 18.3), spleen (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

See PPP1R35 in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100435282..100436698, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101675360..101676575, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100032905..100034120, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger CW-type and PWWP domain containing 1 Neighboring gene methylphosphate capping enzyme Neighboring gene PPP1R35 antisense RNA 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3510 Neighboring gene TSC22D4-C7orf61 readthrough Neighboring gene sperm acrosome developmental regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in notochord morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of centriole elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 35
Names
UPF0683 protein C7orf47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346938.2NP_001333867.1  protein phosphatase 1 regulatory subunit 35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC092849
  2. NM_145030.4NP_659467.1  protein phosphatase 1 regulatory subunit 35 isoform 1

    See identical proteins and their annotated locations for NP_659467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092849, AI433518, BC026269, BI752874
    Consensus CDS
    CCDS5694.1
    UniProtKB/Swiss-Prot
    A4D2C5, Q8TAP8
    Related
    ENSP00000292330.2, ENST00000292330.3
    Conserved Domains (1) summary
    pfam15503
    Location:104248
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100435282..100436698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515914.2XP_011514216.1  protein phosphatase 1 regulatory subunit 35 isoform X1

    Conserved Domains (1) summary
    pfam15503
    Location:34178
    PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101675360..101676575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)