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FCN1 ficolin 1 [ Homo sapiens (human) ]

Gene ID: 2219, updated on 7-Dec-2018

Summary

Official Symbol
FCN1provided by HGNC
Official Full Name
ficolin 1provided by HGNC
Primary source
HGNC:HGNC:3623
See related
Ensembl:ENSG00000085265 MIM:601252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCNM
Summary
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 318.5), appendix (RPKM 117.5) and 3 other tissues See more
Orthologs

Genomic context

See FCN1 in Genome Data Viewer
Location:
9q34.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (134903236..134918003, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137797711..137809849, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101448202 Neighboring gene microRNA 3689f Neighboring gene ficolin 2 Neighboring gene uncharacterized LOC105376314 Neighboring gene uncharacterized LOC105376313

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 significantly inhibits FCN1 expression in human PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
  • Creation of C4 and C2 activators, organism-specific biosystem (from REACTOME)
    Creation of C4 and C2 activators, organism-specific biosystemTwo pathways lead to a complex capable of activating C4 and C2.The classical pathway is triggered by activation of the C1-complex, which consists of hexameric molecule C1q and a tetramer comprising t...
  • Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystem (from REACTOME)
    Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystemFicolins are recognition molecules in the lectin pathway of complement activation. Three types of ficolin have been identified in humans: M-ficolin (ficolin-1, FCN1), L-ficolin (ficolin-2, FCN2) and ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Initial triggering of complement, organism-specific biosystem (from REACTOME)
    Initial triggering of complement, organism-specific biosystemComplement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by t...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lectin pathway of complement activation, organism-specific biosystem (from REACTOME)
    Lectin pathway of complement activation, organism-specific biosystemActivation of the lectin pathway (LP) is initiated by Mannose-binding lectin (MBL), the hetero-complex CL-LK formed from COLEC11 (Collectin liver 1, CL-L1) and COLEC10 (Collectin kidney 1, CL-K1), an...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
complement activation TAS
Traceable Author Statement
more info
 
complement activation, lectin pathway TAS
Traceable Author Statement
more info
 
negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ficolin-1
Names
M-ficolin
ficolin (collagen/fibrinogen domain-containing) 1
ficolin-A
ficolin-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046982.2 RefSeqGene

    Range
    4958..19725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002003.5NP_001994.2  ficolin-1 precursor

    See identical proteins and their annotated locations for NP_001994.2

    Status: REVIEWED

    Source sequence(s)
    AK314867, AL353611, AL603650, AL833097, BC020635, DA813504
    Consensus CDS
    CCDS6985.1
    UniProtKB/Swiss-Prot
    O00602
    Related
    ENSP00000360871.3, ENST00000371806.3
    Conserved Domains (2) summary
    pfam01391
    Location:51107
    Collagen; Collagen triple helix repeat (20 copies)
    cd00087
    Location:115325
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    134903236..134918003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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