U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 [ Mus musculus (house mouse) ]

Gene ID: 22185, updated on 8-Dec-2022

Summary

Official Symbol
U2af2provided by MGI
Official Full Name
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2provided by MGI
Primary source
MGI:MGI:98886
See related
Ensembl:ENSMUSG00000030435 AllianceGenome:MGI:98886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
65kDa
Summary
Enables C2H2 zinc finger domain binding activity. Involved in RNA splicing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type spliceosomal complex; and U2AF complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; liver lobe; lower urinary tract; and nose. Orthologous to human U2AF2 (U2 small nuclear RNA auxiliary factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.3), CNS E14 (RPKM 83.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See U2af2 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5063884..5082944)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5060885..5079945)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 580 Neighboring gene predicted gene 15510 Neighboring gene coiled-coil domain containing 106 Neighboring gene epsin 1 Neighboring gene ret finger protein-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118033

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly-pyrimidine tract binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type prespliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U2AF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2AF complex ISO
Inferred from Sequence Orthology
more info
 
part_of commitment complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear speck TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
splicing factor U2AF 65 kDa subunit
Names
U2 auxiliary factor 65 kDa subunit
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa
U2 snRNP auxiliary factor large subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205231.2NP_001192160.1  splicing factor U2AF 65 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_001192160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC162893
    Consensus CDS
    CCDS57476.1
    UniProtKB/Swiss-Prot
    P26369
    UniProtKB/TrEMBL
    A0A6P5PZ86, A0A8C6H2C3
    Related
    ENSMUSP00000147013.2, ENSMUST00000209099.2
    Conserved Domains (1) summary
    TIGR01642
    Location:63474
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  2. NM_001403145.1NP_001390074.1  splicing factor U2AF 65 kDa subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162893
  3. NM_001403146.1NP_001390075.1  splicing factor U2AF 65 kDa subunit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162893
  4. NM_001403147.1NP_001390076.1  splicing factor U2AF 65 kDa subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162893
  5. NM_001403148.1NP_001390077.1  splicing factor U2AF 65 kDa subunit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  6. NM_001403149.1NP_001390078.1  splicing factor U2AF 65 kDa subunit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  7. NM_001403150.1NP_001390079.1  splicing factor U2AF 65 kDa subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  8. NM_001403151.1NP_001390080.1  splicing factor U2AF 65 kDa subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  9. NM_001403153.1NP_001390082.1  splicing factor U2AF 65 kDa subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  10. NM_001403154.1NP_001390083.1  splicing factor U2AF 65 kDa subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/TrEMBL
    Q3KQM4
  11. NM_001403155.1NP_001390084.1  splicing factor U2AF 65 kDa subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/TrEMBL
    Q3KQM4
  12. NM_001403156.1NP_001390085.1  splicing factor U2AF 65 kDa subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/TrEMBL
    Q3KQM4
  13. NM_001403158.1NP_001390087.1  splicing factor U2AF 65 kDa subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/TrEMBL
    Q3KQM4
  14. NM_001403159.1NP_001390088.1  splicing factor U2AF 65 kDa subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/TrEMBL
    Q3KQM4
  15. NM_133671.4NP_598432.2  splicing factor U2AF 65 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_598432.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC162893
    Consensus CDS
    CCDS85208.1
    UniProtKB/TrEMBL
    A0A6P5PU39, Q80XR5
    Related
    ENSMUSP00000005041.9, ENSMUST00000005041.15
    Conserved Domains (1) summary
    TIGR01642
    Location:63470
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5063884..5082944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242366.1XP_030098226.1  splicing factor U2AF 65 kDa subunit isoform X6

    Conserved Domains (1) summary
    TIGR01642
    Location:1310
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  2. XM_030242369.1XP_030098229.1  splicing factor U2AF 65 kDa subunit isoform X7

    Conserved Domains (1) summary
    TIGR01642
    Location:1306
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  3. XM_030242365.1XP_030098225.1  splicing factor U2AF 65 kDa subunit isoform X5

    Conserved Domains (1) summary
    TIGR01642
    Location:1366
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  4. XM_030242367.1XP_030098227.1  splicing factor U2AF 65 kDa subunit isoform X6

    Conserved Domains (1) summary
    TIGR01642
    Location:1310
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  5. XM_030242368.1XP_030098228.1  splicing factor U2AF 65 kDa subunit isoform X7

    Related
    ENSMUSP00000131458.2, ENSMUST00000165399.2
    Conserved Domains (1) summary
    TIGR01642
    Location:1306
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  6. XM_006539728.4XP_006539791.1  splicing factor U2AF 65 kDa subunit isoform X3

    Conserved Domains (1) summary
    TIGR01642
    Location:4455
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  7. XM_006539727.5XP_006539790.1  splicing factor U2AF 65 kDa subunit isoform X2

    Conserved Domains (1) summary
    TIGR01642
    Location:4459
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  8. XM_030242364.1XP_030098224.1  splicing factor U2AF 65 kDa subunit isoform X1

    UniProtKB/TrEMBL
    A0A6P5PU39, Q80XR5
    Conserved Domains (1) summary
    TIGR01642
    Location:63470
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  9. XM_017322124.3XP_017177613.1  splicing factor U2AF 65 kDa subunit isoform X4

    Conserved Domains (1) summary
    TIGR01642
    Location:1370
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
  10. XM_036152913.1XP_036008806.1  splicing factor U2AF 65 kDa subunit isoform X4

    Conserved Domains (1) summary
    TIGR01642
    Location:1370
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor