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POLR1F RNA polymerase I subunit F [ Homo sapiens (human) ]

Gene ID: 221830, updated on 15-Jan-2022

Summary

Official Symbol
POLR1Fprovided by HGNC
Official Full Name
RNA polymerase I subunit Fprovided by HGNC
Primary source
HGNC:HGNC:18027
See related
Ensembl:ENSG00000105849 MIM:608312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A43; RPA43; TWISTNB
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in DNA-templated transcription, initiation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in endometrium (RPKM 8.5), bone marrow (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See POLR1F in Genome Data Viewer
Location:
7p21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (19695461..19709037, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (19735084..19748660, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375179 Neighboring gene uncharacterized LOC105375180 Neighboring gene uncharacterized LOC107986774 Neighboring gene microRNA 3146 Neighboring gene transmembrane protein 196 Neighboring gene uncharacterized LOC105379720

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA43
Names
DNA-directed RNA polymerase I subunit F
twist neighbor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002926.2NP_001002926.1  DNA-directed RNA polymerase I subunit RPA43

    See identical proteins and their annotated locations for NP_001002926.1

    Status: VALIDATED

    Source sequence(s)
    AC004940, AK090846, BC056267
    Consensus CDS
    CCDS34606.1
    UniProtKB/Swiss-Prot
    Q3B726
    Related
    ENSP00000222567.5, ENST00000222567.6
    Conserved Domains (2) summary
    cd04328
    Location:40126
    RNAP_I_Rpa43_N; Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP ...
    pfam17875
    Location:125157
    RPA43_OB; RPA43 OB domain in RNA Pol I

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    19695461..19709037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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