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Tyrp1 tyrosinase-related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22178, updated on 27-Nov-2024

Summary

Official Symbol
Tyrp1provided by MGI
Official Full Name
tyrosinase-related protein 1provided by MGI
Primary source
MGI:MGI:98881
See related
Ensembl:ENSMUSG00000005994 AllianceGenome:MGI:98881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b; isa; Oca3; TRP1; Tyrp; TRP-1; brown
Summary
Enables protein homodimerization activity. Involved in positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including acetoacetic acid metabolic process; melanocyte differentiation; and melanosome organization. Located in melanosome membrane. Is expressed in several structures, including hip; nervous system; sensory organ; skeleton; and skin. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tyrp1 in Genome Data Viewer
Location:
4 C3; 4 37.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (80752360..80769973)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (80834123..80851736)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42304 Neighboring gene STARR-seq mESC enhancer starr_10592 Neighboring gene predicted gene, 57729 Neighboring gene STARR-seq mESC enhancer starr_10593 Neighboring gene STARR-seq mESC enhancer starr_10594 Neighboring gene STARR-seq mESC enhancer starr_10595 Neighboring gene leucine rich adaptor protein 1-like Neighboring gene STARR-seq mESC enhancer starr_10596 Neighboring gene STARR-seq mESC enhancer starr_10597 Neighboring gene STARR-seq mESC enhancer starr_10598 Neighboring gene multiple PDZ domain crumbs cell polarity complex component Neighboring gene predicted gene, 25803

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically and radiation induced (1) 
  • Chemically induced (ENU) (10) 
  • Chemically induced (other) (14)  1 citation
  • Endonuclease-mediated (4) 
  • Radiation induced (28)  1 citation
  • Spontaneous (8)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tyrosinase activity ISO
Inferred from Sequence Orthology
more info
 
enables tyrosinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated endocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5,6-dihydroxyindole-2-carboxylic acid oxidase
Names
DHICA oxidase
brown locus protein
catalase B
iris stromal atrophy
NP_001268943.1
NP_001268944.1
NP_112479.1
XP_006537844.1
XP_006537845.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282014.1NP_001268943.1  5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

    See identical proteins and their annotated locations for NP_001268943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK148332, AL670884, BC076598
    Consensus CDS
    CCDS18290.1
    UniProtKB/Swiss-Prot
    P07147
    UniProtKB/TrEMBL
    Q3UFK6, Q3UFS3
    Conserved Domains (1) summary
    pfam00264
    Location:183417
    Tyrosinase; Common central domain of tyrosinase
  2. NM_001282015.1NP_001268944.1  5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

    See identical proteins and their annotated locations for NP_001268944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK148332, AL670884, X03687
    Consensus CDS
    CCDS18290.1
    UniProtKB/Swiss-Prot
    P07147
    UniProtKB/TrEMBL
    Q3UFK6, Q3UFS3
    Related
    ENSMUSP00000099895.2, ENSMUST00000102831.8
    Conserved Domains (1) summary
    pfam00264
    Location:183417
    Tyrosinase; Common central domain of tyrosinase
  3. NM_031202.3NP_112479.1  5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

    See identical proteins and their annotated locations for NP_112479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK148332, AL670884, BC076598
    Consensus CDS
    CCDS18290.1
    UniProtKB/Swiss-Prot
    P07147
    UniProtKB/TrEMBL
    Q3UFK6, Q3UFS3
    Related
    ENSMUSP00000006151.7, ENSMUST00000006151.13
    Conserved Domains (1) summary
    pfam00264
    Location:183417
    Tyrosinase; Common central domain of tyrosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    80752360..80769973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537781.2XP_006537844.1  5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_006537844.1

    UniProtKB/TrEMBL
    Q3UFK6
    Conserved Domains (1) summary
    pfam00264
    Location:183417
    Tyrosinase; Common central domain of tyrosinase
  2. XM_006537782.1XP_006537845.1  5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_006537845.1

    UniProtKB/TrEMBL
    Q3UFK6
    Conserved Domains (1) summary
    pfam00264
    Location:183417
    Tyrosinase; Common central domain of tyrosinase