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Tyrobp TYRO protein tyrosine kinase binding protein [ Mus musculus (house mouse) ]

Gene ID: 22177, updated on 12-Aug-2019

Summary

Official Symbol
Tyrobpprovided by MGI
Official Full Name
TYRO protein tyrosine kinase binding proteinprovided by MGI
Primary source
MGI:MGI:1277211
See related
Ensembl:ENSMUSG00000030579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly83; DAP12; KARAP
Expression
Broad expression in spleen adult (RPKM 223.3), lung adult (RPKM 120.3) and 21 other tissues See more
Orthologs

Genomic context

See Tyrobp in Genome Data Viewer
Location:
7 B1; 7 17.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30413782..30417582)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31198807..31202601)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42376 Neighboring gene predicted gene, 32029 Neighboring gene hematopoietic cell signal transducer Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
forebrain development IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
microglial cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid leukocyte activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-10 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transforming growth factor beta1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hippocampal neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage fusion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microglial cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of osteoclast development IGI
Inferred from Genetic Interaction
more info
PubMed 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TYRO protein tyrosine kinase-binding protein
Names
DNAX-activation protein 12
KAR-associated protein
killer cell activating receptor associated protein
killer-activating receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011662.3NP_035792.1  TYRO protein tyrosine kinase-binding protein precursor

    See identical proteins and their annotated locations for NP_035792.1

    Status: VALIDATED

    Source sequence(s)
    AA242315, BC056450
    Consensus CDS
    CCDS21089.1
    UniProtKB/Swiss-Prot
    O54885
    UniProtKB/TrEMBL
    Q3U419
    Related
    ENSMUSP00000032800.9, ENSMUST00000032800.9
    Conserved Domains (1) summary
    pfam07213
    Location:2272
    DAP10; DAP10 membrane protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p6 C57BL/6J

    Range
    30413782..30417582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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