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FCGRT Fc gamma receptor and transporter [ Homo sapiens (human) ]

Gene ID: 2217, updated on 17-Sep-2024

Summary

Official Symbol
FCGRTprovided by HGNC
Official Full Name
Fc gamma receptor and transporterprovided by HGNC
Primary source
HGNC:HGNC:3621
See related
Ensembl:ENSG00000104870 MIM:601437; AllianceGenome:HGNC:3621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRN; FcgammaRn; alpha-chain
Summary
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See FCGRT in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49512661..49526428)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52512666..52526423)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50015918..50029685)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003846-50004617 Neighboring gene Sharpr-MPRA regulatory region 15417 Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50014938-50015500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50017428-50018141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene nitric oxide synthase interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS
Non-traceable Author Statement
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment of IgG receptor and transporter
Fc fragment of IgG, receptor, transporter, alpha
FcRn alpha chain
IgG Fc fragment receptor transporter alpha chain
heavy chain of the major histocompatibility complex class I-like Fc receptor
immunoglobulin receptor, intestinal, heavy chain
major histocompatibility complex class I-like Fc receptor
neonatal Fc receptor
neonatal Fc-receptor for Ig
neonatal fragment crystallizable Fc receptor FcRn
transmembrane alpha chain of the neonatal receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136019.3NP_001129491.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC010619, BC091487, BE245284
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
    Related
    ENSP00000221466.4, ENST00000221466.10
    Conserved Domains (2) summary
    cd21011
    Location:198290
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. NM_001411064.1NP_001397993.1  IgG receptor FcRn large subunit p51 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1 and skips an internal exon. It encodes a shorter protein (2), compared to isoform 1.
    Source sequence(s)
    AC010619
    Consensus CDS
    CCDS92663.1
    UniProtKB/TrEMBL
    M0R0A9
    Related
    ENSP00000471118.1, ENST00000596975.5
  3. NM_004107.5NP_004098.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC008734, BE245284
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
    Related
    ENSP00000410798.2, ENST00000426395.7
    Conserved Domains (2) summary
    cd21011
    Location:198290
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49512661..49526428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438411.1XP_047294367.1  IgG receptor FcRn large subunit p51 isoform X3

  2. XM_047438408.1XP_047294364.1  IgG receptor FcRn large subunit p51 isoform X1

  3. XM_047438410.1XP_047294366.1  IgG receptor FcRn large subunit p51 isoform X2

    UniProtKB/TrEMBL
    M0QYN1
  4. XM_047438412.1XP_047294368.1  IgG receptor FcRn large subunit p51 isoform X4

    UniProtKB/TrEMBL
    M0QYN1
    Related
    ENSP00000469933.1, ENST00000600273.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52512666..52526423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320202.1XP_054176177.1  IgG receptor FcRn large subunit p51 isoform X3

  2. XM_054320200.1XP_054176175.1  IgG receptor FcRn large subunit p51 isoform X1

  3. XM_054320201.1XP_054176176.1  IgG receptor FcRn large subunit p51 isoform X2

    UniProtKB/TrEMBL
    M0QYN1
  4. XM_054320203.1XP_054176178.1  IgG receptor FcRn large subunit p51 isoform X4

    UniProtKB/TrEMBL
    M0QYN1
  5. XM_054320199.1XP_054176174.1  IgG receptor FcRn large subunit p51 isoform X5

    UniProtKB/Swiss-Prot
    P55899, Q5HYM5, Q9HBV7, Q9NZ19
    UniProtKB/TrEMBL
    A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1