Format

Send to:

Choose Destination

FCGRT Fc fragment of IgG receptor and transporter [ Homo sapiens (human) ]

Gene ID: 2217, updated on 8-Jul-2018
Official Symbol
FCGRTprovided by HGNC
Official Full Name
Fc fragment of IgG receptor and transporterprovided by HGNC
Primary source
HGNC:HGNC:3621
See related
Ensembl:ENSG00000104870 MIM:601437; Vega:OTTHUMG00000183155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRN; alpha-chain
Summary
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more
Orthologs
See FCGRT in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49512279..49526428)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50015536..50029685)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7 Neighboring gene reticulocalbin 3 Neighboring gene nitric oxide synthase interacting protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS
Non-traceable Author Statement
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment of IgG, receptor, transporter, alpha
FcRn alpha chain
IgG Fc fragment receptor transporter alpha chain
heavy chain of the major histocompatibility complex class I-like Fc receptor
immunoglobulin receptor, intestinal, heavy chain
major histocompatibility complex class I-like Fc receptor
neonatal Fc receptor
neonatal Fc-receptor for Ig
transmembrane alpha chain of the neonatal receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136019.2NP_001129491.1  IgG receptor FcRn large subunit p51 precursor

    See identical proteins and their annotated locations for NP_001129491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010619, BC091487, BE245284, BI520292
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899
    UniProtKB/TrEMBL
    A0A024QZI2
    Related
    ENSP00000221466.4, OTTHUMP00000270959, ENST00000221466.9, OTTHUMT00000465267
    Conserved Domains (2) summary
    cl08246
    Location:25197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:201291
    Ig; Immunoglobulin domain
  2. NM_004107.4NP_004098.1  IgG receptor FcRn large subunit p51 precursor

    See identical proteins and their annotated locations for NP_004098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC008734, BE245284, DC312637
    Consensus CDS
    CCDS12770.1
    UniProtKB/Swiss-Prot
    P55899
    UniProtKB/TrEMBL
    A0A024QZI2
    Related
    ENSP00000410798.2, OTTHUMP00000270962, ENST00000426395.7, OTTHUMT00000465270
    Conserved Domains (2) summary
    cl08246
    Location:25197
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:201291
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    49512279..49526428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center