U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cmpk2 cytidine/uridine monophosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 22169, updated on 19-Jun-2024

Summary

Official Symbol
Cmpk2provided by MGI
Official Full Name
cytidine/uridine monophosphate kinase 2provided by MGI
Primary source
MGI:MGI:99830
See related
Ensembl:ENSMUSG00000020638 AllianceGenome:MGI:99830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TDKI; Tyki; 1200004E04Rik
Summary
Predicted to enable nucleobase-containing compound kinase activity. Acts upstream of or within cellular response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including adrenal gland; genitourinary system; gut gland; liver; and nervous system. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 11.2), adrenal adult (RPKM 9.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cmpk2 in Genome Data Viewer
Location:
12 A2; 12 9.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (26519121..26529836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (26469117..26479837)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 144A Neighboring gene microRNA 6538 Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene predicted gene, 46344 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:27209914-27210115 Neighboring gene RIKEN cDNA 1700020D12 gene Neighboring gene STARR-seq mESC enhancer starr_31789 Neighboring gene STARR-seq mESC enhancer starr_31790

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (d)CMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables (d)CMP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables UMP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables UMP/dUMP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleoside monophosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thymidylate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dTDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dUDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UMP-CMP kinase 2, mitochondrial
Names
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
nucleoside-diphosphate kinase
thymidylate kinase LPS-inducible member
thymidylate kinase homologue
NP_065582.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020557.4NP_065582.3  UMP-CMP kinase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_065582.3

    Status: VALIDATED

    Source sequence(s)
    BC057565, CA528639
    Consensus CDS
    CCDS49039.1
    UniProtKB/Swiss-Prot
    Q3U5Q7, Q3UCI7, Q5XKG5, Q62316, Q6PFG7, Q9DC34
    Related
    ENSMUSP00000020969.4, ENSMUST00000020969.5
    Conserved Domains (2) summary
    COG0125
    Location:248443
    Tmk; Thymidylate kinase [Nucleotide transport and metabolism]
    cl17190
    Location:255444
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    26519121..26529836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950046.2 RNA Sequence

  2. XR_381188.5 RNA Sequence