Format

Send to:

Choose Destination

RNF182 ring finger protein 182 [ Homo sapiens (human) ]

Gene ID: 221687, updated on 23-Nov-2021

Summary

Official Symbol
RNF182provided by HGNC
Official Full Name
ring finger protein 182provided by HGNC
Primary source
HGNC:HGNC:28522
See related
Ensembl:ENSG00000180537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 4.5), bone marrow (RPKM 2.7) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RNF182 in Genome Data Viewer
Location:
6p23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (13924446..13980310)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13924677..13980541)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene uncharacterized LOC107986571 Neighboring gene CRISPRi-validated cis-regulatory element chr6.697 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr6.702 Neighboring gene CRISPRi-validated cis-regulatory element chr6.703

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40772, MGC33993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF182
Names
RING-type E3 ubiquitin transferase RNF182
NP_001158504.1
NP_001158505.1
NP_001158506.1
NP_689950.1
XP_016865939.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165032.2NP_001158504.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158504.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL138718, AW731636, BC030666, BC050030, DA803766, DB094450
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    Q8N6D2
    UniProtKB/TrEMBL
    A0A024QZW5
    Related
    ENSP00000442021.1, ENST00000544682.5
    Conserved Domains (1) summary
    cd16555
    Location:1969
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
  2. NM_001165033.2NP_001158505.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK090576, AL138718, AW731636, BC030666, BC050030, DB176198
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    Q8N6D2
    UniProtKB/TrEMBL
    A0A024QZW5
    Related
    ENSP00000441271.1, ENST00000537388.1
    Conserved Domains (1) summary
    cd16555
    Location:1969
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
  3. NM_001165034.2NP_001158506.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL138718, AW731636, BC030666, BC050030, DA123125
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    Q8N6D2
    UniProtKB/TrEMBL
    A0A024QZW5
    Related
    ENSP00000443228.1, ENST00000537663.5
    Conserved Domains (1) summary
    cd16555
    Location:1969
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
  4. NM_152737.4NP_689950.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_689950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK315528, AL138718, AW731636, BC030666, BC050030
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    Q8N6D2
    UniProtKB/TrEMBL
    A0A024QZW5
    Related
    ENSP00000420465.1, ENST00000488300.6
    Conserved Domains (1) summary
    cd16555
    Location:1969
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    13924446..13980310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010450.2XP_016865939.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    Q8N6D2
    UniProtKB/TrEMBL
    A0A024QZW5
    Conserved Domains (1) summary
    cd16555
    Location:1969
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
Support Center