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RBM24 RNA binding motif protein 24 [ Homo sapiens (human) ]

Gene ID: 221662, updated on 12-Oct-2019

Summary

Official Symbol
RBM24provided by HGNC
Official Full Name
RNA binding motif protein 24provided by HGNC
Primary source
HGNC:HGNC:21539
See related
Ensembl:ENSG00000112183 MIM:617603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNPC6; dJ259A10.1
Expression
Biased expression in heart (RPKM 42.8), endometrium (RPKM 14.9) and 4 other tissues See more
Orthologs

Genomic context

See RBM24 in Genome Data Viewer
Location:
6p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (17281361..17293875)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (17281739..17294102)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374951 Neighboring gene uncharacterized LOC101928463 Neighboring gene stathmin domain containing 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 96/97 Neighboring gene esterase D/formylglutathione hydrolase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26355, FLJ30829, FLJ37697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA CDS binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA intronic binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of 3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle fiber differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 24
Names
RNA-binding region (RNP1, RRM) containing 6
RNA-binding region-containing protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143941.1NP_001137413.1  RNA-binding protein 24 isoform 3

    See identical proteins and their annotated locations for NP_001137413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK055391, AL136305, BC040928, BP309176
    Consensus CDS
    CCDS47379.1
    UniProtKB/Swiss-Prot
    Q9BX46
    Related
    ENSP00000396898.2, ENST00000425446.6
    Conserved Domains (1) summary
    cl17169
    Location:128
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001143942.2NP_001137414.1  RNA-binding protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001137414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK315856, AL136305, BC040928
    Consensus CDS
    CCDS47378.1
    UniProtKB/Swiss-Prot
    Q9BX46
    UniProtKB/TrEMBL
    A8KAI7
    Related
    ENSP00000368341.5, ENST00000379052.10
    Conserved Domains (1) summary
    cd12384
    Location:1186
    RRM_RBM24_RBM38_like; RNA recognition motif in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins
  3. NM_153020.2NP_694565.1  RNA-binding protein 24 isoform 2

    See identical proteins and their annotated locations for NP_694565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK055391, AL136305, BC040928
    Consensus CDS
    CCDS4538.1
    UniProtKB/Swiss-Prot
    Q9BX46
    Related
    ENSP00000319551.5, ENST00000318204.5
    Conserved Domains (1) summary
    cl17169
    Location:1241
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    17281361..17293875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248932.3XP_005248989.1  RNA-binding protein 24 isoform X4

    Conserved Domains (2) summary
    COG0724
    Location:593
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12384
    Location:1186
    RRM_RBM24_RBM38_like; RNA recognition motif in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins
  2. XM_011514387.2XP_011512689.1  RNA-binding protein 24 isoform X1

    Conserved Domains (1) summary
    cl17169
    Location:128
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011514388.2XP_011512690.1  RNA-binding protein 24 isoform X2

    See identical proteins and their annotated locations for XP_011512690.1

    UniProtKB/TrEMBL
    B7Z6B7
  4. XM_011514389.2XP_011512691.1  RNA-binding protein 24 isoform X3

    See identical proteins and their annotated locations for XP_011512691.1

    UniProtKB/TrEMBL
    B7Z6B4
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