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Tuft1 tuftelin 1 [ Mus musculus (house mouse) ]

Gene ID: 22156, updated on 8-Feb-2025

Summary

Official Symbol
Tuft1provided by MGI
Official Full Name
tuftelin 1provided by MGI
Primary source
MGI:MGI:109572
See related
Ensembl:ENSMUSG00000005968 AllianceGenome:MGI:109572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 11.2), small intestine adult (RPKM 10.2) and 25 other tissues See more
Orthologs
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Genomic context

See Tuft1 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94520060..94566179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94612753..94658872, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene ribosomal protein L31, pseudogene 11 Neighboring gene cingulin pseudogene Neighboring gene STARR-seq mESC enhancer starr_08354 Neighboring gene selenium binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of skin epidermis ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of skin epidermis ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293728.1NP_001280657.1  tuftelin isoform 2

    See identical proteins and their annotated locations for NP_001280657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC127252
    Consensus CDS
    CCDS79975.1
    UniProtKB/TrEMBL
    A0A0G2JDW8, Q3TAP8
    Related
    ENSMUSP00000143278.2, ENSMUST00000196733.5
    Conserved Domains (1) summary
    pfam06364
    Location:125214
    DUF1068; Protein of unknown function (DUF1068)
  2. NM_011656.3NP_035786.1  tuftelin isoform 1

    See identical proteins and their annotated locations for NP_035786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127252, AK132488
    Consensus CDS
    CCDS17595.1
    UniProtKB/Swiss-Prot
    O08970
    UniProtKB/TrEMBL
    A0A0G2JDW8, Q3V1F5
    Related
    ENSMUSP00000006123.4, ENSMUST00000006123.11
    Conserved Domains (1) summary
    pfam06364
    Location:150239
    DUF1068; Protein of unknown function (DUF1068)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94520060..94566179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501307.3XP_006501370.1  tuftelin isoform X1

    See identical proteins and their annotated locations for XP_006501370.1

    UniProtKB/TrEMBL
    A0A0G2JDW8
    Conserved Domains (1) summary
    TIGR02169
    Location:41284
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type