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PI16 peptidase inhibitor 16 [ Homo sapiens (human) ]

Gene ID: 221476, updated on 21-Dec-2019

Summary

Official Symbol
PI16provided by HGNC
Official Full Name
peptidase inhibitor 16provided by HGNC
Primary source
HGNC:HGNC:21245
See related
Ensembl:ENSG00000164530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD364; PSPBP; CRISP9; MSMBBP
Expression
Biased expression in urinary bladder (RPKM 35.7), heart (RPKM 28.3) and 12 other tissues See more
Orthologs

Genomic context

See PI16 in Genome Data Viewer
Location:
6p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (36948263..36964837)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36916039..36932613)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene copine 5 Neighboring gene chromosome 6 open reading frame 89 Neighboring gene peptidylprolyl isomerase like 1 Neighboring gene mitochondrial carrier 1 Neighboring gene FYVE, RhoGEF and PH domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Chemerin, a novel adipokine in the regulation of angiogenesis.
NHGRI GWA Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC45378, DKFZp586B1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptidase inhibitor 16
Names
PSP94-binding protein
cysteine-rich secretory protein 9
microseminoprotein, beta-binding protein
protease inhibitor 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199159.1NP_001186088.1  peptidase inhibitor 16 precursor

    See identical proteins and their annotated locations for NP_001186088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL050088, BC022399, DA342875, DB178215
    Consensus CDS
    CCDS34440.1
    UniProtKB/Swiss-Prot
    Q6UXB8
    Related
    ENSP00000478888.1, ENST00000611814.4
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
  2. NM_153370.3NP_699201.2  peptidase inhibitor 16 precursor

    See identical proteins and their annotated locations for NP_699201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL050088, BC022399, BC035634
    Consensus CDS
    CCDS34440.1
    UniProtKB/Swiss-Prot
    Q6UXB8
    Related
    ENSP00000362778.3, ENST00000373674.4
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    36948263..36964837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514375.3XP_011512677.1  peptidase inhibitor 16 isoform X1

    See identical proteins and their annotated locations for XP_011512677.1

    UniProtKB/Swiss-Prot
    Q6UXB8
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
  2. XM_017010430.2XP_016865919.1  peptidase inhibitor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q6UXB8
    Conserved Domains (1) summary
    cl00133
    Location:33166
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  3. XM_005248917.3XP_005248974.1  peptidase inhibitor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q6UXB8
    Conserved Domains (1) summary
    cl00133
    Location:33166
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
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