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PI16 peptidase inhibitor 16 [ Homo sapiens (human) ]

Gene ID: 221476, updated on 5-Aug-2022

Summary

Official Symbol
PI16provided by HGNC
Official Full Name
peptidase inhibitor 16provided by HGNC
Primary source
HGNC:HGNC:21245
See related
Ensembl:ENSG00000164530 AllianceGenome:HGNC:21245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD364; PSPBP; CRISP9; MSMBBP
Summary
Predicted to enable peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in urinary bladder (RPKM 35.7), heart (RPKM 28.3) and 12 other tissues See more
Orthologs
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Genomic context

See PI16 in Genome Data Viewer
Location:
6p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36948296..36964837)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36771401..36787902)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36916072..36932613)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 1 Neighboring gene chromosome 6 open reading frame 89 Neighboring gene Sharpr-MPRA regulatory region 12138 Neighboring gene mitochondrial carrier 1 Neighboring gene FYVE, RhoGEF and PH domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Chemerin, a novel adipokine in the regulation of angiogenesis.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45378, DKFZp586B1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptidase inhibitor 16
Names
PSP94-binding protein
cysteine-rich secretory protein 9
microseminoprotein, beta-binding protein
protease inhibitor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199159.2NP_001186088.1  peptidase inhibitor 16 precursor

    See identical proteins and their annotated locations for NP_001186088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL050088, BC022399, DA342875, DB178215
    Consensus CDS
    CCDS34440.1
    UniProtKB/Swiss-Prot
    Q6UXB8, Q8TCB8
    Related
    ENSP00000478888.1, ENST00000611814.4
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
  2. NM_153370.3NP_699201.2  peptidase inhibitor 16 precursor

    See identical proteins and their annotated locations for NP_699201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL050088, BC022399, BC035634
    Consensus CDS
    CCDS34440.1
    UniProtKB/Swiss-Prot
    Q6UXB8, Q8TCB8
    Related
    ENSP00000362778.3, ENST00000373674.4
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36948296..36964837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514375.4XP_011512677.1  peptidase inhibitor 16 isoform X1

    See identical proteins and their annotated locations for XP_011512677.1

    UniProtKB/Swiss-Prot
    Q6UXB8, Q8TCB8
    Conserved Domains (1) summary
    cd05559
    Location:33166
    SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
  2. XM_017010430.3XP_016865919.1  peptidase inhibitor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q6UXB8
    Conserved Domains (1) summary
    cl00133
    Location:33166
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  3. XM_005248917.4XP_005248974.1  peptidase inhibitor 16 isoform X2

    UniProtKB/Swiss-Prot
    Q6UXB8
    Conserved Domains (1) summary
    cl00133
    Location:33166
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36771401..36787902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)