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Tuba1b tubulin, alpha 1B [ Mus musculus (house mouse) ]

Gene ID: 22143, updated on 9-Dec-2024

Summary

Official Symbol
Tuba1bprovided by MGI
Official Full Name
tubulin, alpha 1Bprovided by MGI
Primary source
MGI:MGI:107804
See related
Ensembl:ENSMUSG00000023004 AllianceGenome:MGI:107804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tuba2
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within cellular response to interleukin-4. Located in cytoplasmic microtubule. Is expressed in several structures, including cerebral cortex; genitourinary system; hemolymphoid system gland; liver; and retina layer. Orthologous to human TUBA1B (tubulin alpha 1b). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 1592.2), CNS E18 (RPKM 1414.4) and 28 other tissues See more
Orthologs
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Genomic context

See Tuba1b in Genome Data Viewer
Location:
15 F1; 15 55.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98829310..98832271, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98931429..98934390, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene desert hedgehog Neighboring gene limb region 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr15:98748573-98748874 Neighboring gene predicted gene, 41396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98764367-98764476 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98783649-98783758 Neighboring gene STARR-positive B cell enhancer ABC_E7416 Neighboring gene RIKEN cDNA B430209F14 gene Neighboring gene tubulin, alpha 1A Neighboring gene VISTA enhancer mm1449

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102558, MGC117866, MGC118411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
tubulin alpha-1B chain
Names
alpha-tubulin 2
alpha-tubulin isotype M-alpha-2
tubulin alpha-2 chain
tubulin, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011654.2NP_035784.1  tubulin alpha-1B chain

    See identical proteins and their annotated locations for NP_035784.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108394
    Consensus CDS
    CCDS37195.1
    UniProtKB/Swiss-Prot
    P05213, Q3TY23, Q3U8B1, Q3UAW8, Q4KMW2
    UniProtKB/TrEMBL
    Q3TIZ0
    Related
    ENSMUSP00000076777.8, ENSMUST00000077577.8
    Conserved Domains (1) summary
    PTZ00335
    Location:1440
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98829310..98832271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)