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LRRC73 leucine rich repeat containing 73 [ Homo sapiens (human) ]

Gene ID: 221424, updated on 23-Nov-2021

Summary

Official Symbol
LRRC73provided by HGNC
Official Full Name
leucine rich repeat containing 73provided by HGNC
Primary source
HGNC:HGNC:21375
See related
Ensembl:ENSG00000204052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf154
Expression
Biased expression in testis (RPKM 12.8), brain (RPKM 2.3) and 2 other tissues See more
Orthologs
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Genomic context

See LRRC73 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43506968..43510346, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43474703..43478084, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene tight junction associated protein 1 Neighboring gene RNA polymerase I and III subunit C Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene Yip1 domain family member 3 Neighboring gene exportin 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44836, MGC131686

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012974.4NP_001012992.1  leucine-rich repeat-containing protein 73 isoform 1

    See identical proteins and their annotated locations for NP_001012992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355802
    Consensus CDS
    CCDS34456.1
    UniProtKB/Swiss-Prot
    Q5JTD7
    Related
    ENSP00000361518.1, ENST00000372441.1
    Conserved Domains (2) summary
    sd00033
    Location:5886
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:5255
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_001271882.2NP_001258811.1  leucine-rich repeat-containing protein 73 isoform 2

    See identical proteins and their annotated locations for NP_001258811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL355802, BC107130, BC108661, HY024930
    UniProtKB/Swiss-Prot
    Q5JTD7
    UniProtKB/TrEMBL
    Q3B825
    Conserved Domains (1) summary
    cl39015
    Location:19132
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43506968..43510346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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